DVL1 and BRD7

Number of citations of the paper that reports this interaction (PubMedID 12941796)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DVL1	BRD7
Description		dishevelled segment polarity protein 1	bromodomain containing 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome	Kinetochore Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix RSC-type Complex
	Molecular Function	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Binding Histone H3K14ac Reader Activity Histone Reader Activity
	Biological Process	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Regulation of TP53 Activity through Acetylation Formation of the polybromo-BAF (pBAF) complex
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)	Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2	30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4C16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PARP1 PCBD1 PLEKHF2 PSMD11 PTPN13 RIF1 RPLP1 SERPINB9 TRIM24
Entrez ID		1855	29117
HPRD ID		03220	12531
Ensembl ID		ENSG00000107404	ENSG00000166164
Uniprot IDs		O14640	A0AA34QVS2 Q9NPI1
PDB IDs		6LCA 6LCB 6TTK	2I7K 5MQ1 6PPA 6V0Q 6V16 6V17 6V1E 6V1F 6V1H 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process	Chromatin Remodeling Chromatin Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromosome Chromosome, Telomeric Region Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Nucleus Barr Body Telomere Organization Negative Regulation Of Metabolic Process Protein Localization To Chromatin Heterochromatin Formation Subtelomeric Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Chromatin Cellular Response To Estrogen Stimulus Extracellular Exosome Retrograde Axonal Transport Protein Binding Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Negative Regulation Of MRNA 3'-end Processing Epigenetic Regulation Of Gene Expression Histone H3K9cr Reader Activity Histone H3K27cr Reader Activity Histone H3K18cr Reader Activity Histone H3K23ac Reader Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurotrophin Production Positive Regulation Of ERBB Signaling Pathway Chromosome, Telomeric Repeat Region Regulation Of Developmental Process Growth Cone Response To Mineralocorticoid
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