DVL1 and VANGL2

Number of citations of the paper that reports this interaction (PMID 12490194)
80

Data Source:
HPRD (in vitro)

		DVL1	VANGL2
Gene Name		dishevelled segment polarity protein 1	VANGL planar cell polarity protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Synapse	Stress Fiber Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ER To Golgi Transport Vesicle Cell Pole
	Molecular Function	Molecular_function Frizzled Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding
	Biological Process	Regulation Of Neurotransmitter Levels Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Wnt Signaling Pathway Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Axis Elongation Rho Protein Signal Transduction Anterior/posterior Pattern Specification Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Maintenance Nonmotile Primary Cilium Assembly Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of JUN Kinase Activity Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Inner Ear Receptor Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Planar Cell Polarity Pathway Involved In Heart Morphogenesis Cochlea Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling	Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		35 interactors: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2	2 interactors: DVL1 MAGI3
Entrez ID		1855	57216
HPRD ID		03220	02758
Ensembl ID		ENSG00000107404	ENSG00000162738
Uniprot IDs		O14640 Q86TH3	A8K4L6 Q9ULK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process SMAD Protein Complex Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Proteasomal Protein Catabolic Process Cell Communication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Stem Cell Differentiation Embryonic Axis Specification Regulation Of Phosphorus Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Kidney Development	Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting Convergent Extension Involved In Organogenesis Protein Localization To Microtubule Neural Plate Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Protein Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Kinase Activity Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Prepulse Inhibition Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Localization To Cytoskeleton Regulation Of Protein Phosphorylation Cochlea Morphogenesis Startle Response Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cytoplasmic Microtubule Organization Social Behavior Axon Extension Regulation Of Phosphorus Metabolic Process Cochlea Development Receptor Clustering Neuromuscular Junction Development Negative Regulation Of Protein Binding Nucleotide Phosphorylation Morphogenesis Of An Epithelial Sheet Neuron Projection Extension Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of JUN Kinase Activity Intracellular Signal Transduction Dendrite Morphogenesis Regulation Of JUN Kinase Activity Regulation Of Cellular Protein Metabolic Process Developmental Cell Growth Canonical Wnt Signaling Pathway Negative Regulation Of Binding Inner Ear Morphogenesis Regulation Of Protein Metabolic Process Neurotransmitter Secretion Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway
Tagcloud ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly wiring
Tagcloud (Difference) ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly wiring
Tagcloud (Intersection) ?