DVL1 and SIPA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DVL1	SIPA1
Description		dishevelled segment polarity protein 1	signal-induced proliferation-associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Wnt Signalosome	Nucleus Cytoplasm Cytosol Endomembrane System Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Neurotransmitter Secretion Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Synaptic Vesicle Exocytosis Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Cochlea Morphogenesis Presynapse Assembly Postsynapse Organization Regulation Of Postsynapse Organization Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Adaptive Immune Response Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Growth Intracellular Signal Transduction Cellular Response To Water Deprivation Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Rap1 signalling
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) HDL cholesterol ( 30275531) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet count ( 27863252) Pulse pressure ( 30578418) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618452 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 FZD7 GNAI3 HDHD2 HECW1 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 SNCA TRIM69 USP13 VANGL1 VANGL2	4 interacting genes: CDKN1A COP1 DVL1 SHANK3
Entrez ID		1855	6494
HPRD ID		03220	03713
Ensembl ID		ENSG00000107404	ENSG00000213445
Uniprot IDs		O14640	Q96FS4
PDB IDs		6LCA 6LCB 6TTK
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway I-SMAD Binding Regulation Of Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Signal Transduction Heteromeric SMAD Protein Complex Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process SMAD Protein Complex Cytoplasm Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Response To Growth Factor R-SMAD Binding Positive Regulation Of Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Stability Cellular Response To Growth Factor Stimulus Dorsal/ventral Axis Specification Regulation Of Cellular Component Organization Cytosol Negative Regulation Of Biosynthetic Process	Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Receptor Clustering Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Response To Ionizing Radiation Positive Regulation Of Protein Localization To Presynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynapse Organization Regulation Of Nervous System Process Dendritic Spine Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Guanylate Kinase-associated Protein Clustering Protein Localization To Nucleus Convergent Extension Involved In Neural Plate Elongation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Catabolic Process Synaptic Receptor Adaptor Activity Convergent Extension Involved In Organogenesis Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Postsynaptic Density Synapse Organization Neuron Projection Morphogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Protein Localization To Synapse Oncogene-induced Cell Senescence Stress-induced Premature Senescence Cell Projection Morphogenesis Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Positive Regulation Of Neuron Projection Arborization Regulation Of Synapse Organization Protein Localization To Membrane Vocal Learning
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