DVL1 and TRIM69

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DVL1	TRIM69
Gene Name		dishevelled segment polarity protein 1	tripartite motif containing 69
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Synapse	Nucleus Cytoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Molecular_function Frizzled Binding Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Rac GTPase Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Regulation Of Neurotransmitter Levels Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Wnt Signaling Pathway Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Receptor Clustering Positive Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Apoptotic Process Protein Ubiquitination
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ANXA7 ARRB1 ATN1 AXIN1 BRD7 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FRAT1 HDHD2 HECW1 LRRK2 NCK2 NEDD4 PPM1A PSMA3 RAC1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 TRIM69 USP13 VANGL1 VANGL2	22 interactors: APP ASNS ATP5G1 DVL1 FAM110A FKBP1B HAUS1 IYD KRT17 LARP1B MAGEA4 NEK8 PML PPP1R18 RECK RSPH14 SF1 SF3A3 SKIL SYNE4 TRIM44 ZNF483
Entrez ID		1855	140691
HPRD ID		03220	11518
Ensembl ID		ENSG00000107404	ENSG00000185880
Uniprot IDs		O14640 Q86TH3	Q86WT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Cell Morphogenesis Regulation Of Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process SMAD Protein Complex Assembly Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Proteasomal Protein Catabolic Process Cell Communication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Stem Cell Differentiation Embryonic Axis Specification Regulation Of Phosphorus Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Kidney Development	MRNA 3'-splice Site Recognition Collateral Sprouting Maintenance Of Protein Location In Nucleus Anatomical Structure Development System Development Negative Regulation Of Catalytic Activity Protein Localization To Nucleus Regulation Of Cell Development Developmental Process Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cell Development Morphogenesis Of An Epithelium MRNA Splice Site Selection Multicellular Organismal Development Organ Development Positive Regulation Of Neuron Projection Development Regulation Of Neuron Differentiation Neuromuscular Junction Development Cellular Nitrogen Compound Metabolic Process Epithelium Development Negative Regulation Of Translation In Response To Oxidative Stress L-asparagine Biosynthetic Process Regulation Of Hormone Levels Anatomical Structure Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Tissue Development Regulation Of Translation Spliceosomal Complex Assembly Positive Regulation Of Cell Projection Organization Tissue Morphogenesis Positive Regulation Of Cell Cycle Regulation Of Proteolysis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Cell Differentiation Calcium Ion Homeostasis Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Gene Expression Cellular Component Assembly Regulation Of Calcium Ion Transport Into Cytosol Synaptic Growth At Neuromuscular Junction Positive Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Neuron Differentiation Nitrogen Compound Metabolic Process Response To Light Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Difference) ?		1p36 1q36 20p12 2q37 accumulating boy brachydactyly chr1 chr2 chr20 cnv cnvs coarctation deleted deletion digit duplications dysmorphism facial gpcpd1 hdac4 intellectual malformations p36 pcrs phenotypes simply syndromic tumorigenic
Tagcloud (Intersection) ?