HBEGF and FBLN1

Number of citations of the paper that reports this interaction (PMID 11846885)
3

Data Source:
HPRD (two hybrid)

		HBEGF	FBLN1
Gene Name		heparin-binding EGF-like growth factor	fibulin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Wound Healing	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling EGFR Transactivation by Gastrin PI3K/AKT activation Uptake and actions of bacterial toxins PI-3K cascade GRB2 events in ERBB2 signaling Gastrin-CREB signalling pathway via PKC and MAPK PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Uptake and function of diphtheria toxin	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		11 interactors: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRD1 ZBTB16	35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ
Entrez ID		1839	2192
HPRD ID		00526	00629
Ensembl ID		ENSG00000113070	ENSG00000077942
Uniprot IDs		Q99075	P23142 Q8NBH6
PDB IDs		1XDT
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Single Organism Reproductive Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Regulation Of Protein Metabolic Process Secretion Positive Regulation Of Metabolic Process Reproductive Process Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Regulation Of Cell Death Developmental Process Cell Migration Cell Motility System Development Negative Regulation Of Apoptotic Process Regulation Of Chondrocyte Differentiation Negative Regulation Of Programmed Cell Death Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Mesenchymal Stem Cell Proliferation Transforming Growth Factor Beta Activation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Death Regulation Of Cellular Amino Acid Metabolic Process Organ Development Programmed Cell Death Regulation Of Peptidase Activity Embryonic Pattern Specification Regulation Of Cartilage Development Cell Death Death Regulation Of Protein Phosphorylation	Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?