HBEGF and ZBTB16

Number of citations of the paper that reports this interaction (PMID 14597771)
34

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HBEGF	ZBTB16
Gene Name		heparin-binding EGF-like growth factor	zinc finger and BTB domain containing 16
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Wound Healing	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling EGFR Transactivation by Gastrin PI3K/AKT activation Uptake and actions of bacterial toxins PI-3K cascade GRB2 events in ERBB2 signaling Gastrin-CREB signalling pathway via PKC and MAPK PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Uptake and function of diphtheria toxin	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Conduct disorder (interaction) ( 18846501)
Protein-Protein Interactions		11 interactors: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRD1 ZBTB16	111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		1839	7704
HPRD ID		00526	11762
Ensembl ID		ENSG00000113070	ENSG00000109906
Uniprot IDs		Q99075	Q05516
PDB IDs		1XDT	1BUO 1CS3
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Single Organism Reproductive Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Regulation Of Protein Metabolic Process Secretion Positive Regulation Of Metabolic Process Reproductive Process Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Regulation Of Cell Death Developmental Process Cell Migration Cell Motility System Development Negative Regulation Of Apoptotic Process Regulation Of Chondrocyte Differentiation Negative Regulation Of Programmed Cell Death Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Mesenchymal Stem Cell Proliferation Transforming Growth Factor Beta Activation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Death Regulation Of Cellular Amino Acid Metabolic Process Organ Development Programmed Cell Death Regulation Of Peptidase Activity Embryonic Pattern Specification Regulation Of Cartilage Development Cell Death Death Regulation Of Protein Phosphorylation	Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
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