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FBLN1 and LCE1C
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
FBLN1
LCE1C
Description
fibulin 1
late cornified envelope 1C
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Molecular Function
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Peptidase Activator Activity
Identical Protein Binding
Protein-containing Complex Binding
Fibrinogen Binding
Protein Binding
Biological Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Integrin-mediated Signaling Pathway
Embryo Implantation
Positive Regulation Of Gene Expression
Extracellular Matrix Organization
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Transformation Of Host Cell By Virus
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Cell Motility
Negative Regulation Of Stem Cell Proliferation
Epidermis Development
Keratinization
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Formation of the cornified envelope
Drugs
Diseases
Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS
Blood protein levels (
30072576
)
Colon cancer (
33632709
)
Distal colorectal cancer (
33632709
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Low density lipoprotein cholesterol levels (
32154731
)
Paneth cell defects in Crohn's disease (
28352666
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
QT interval (
29213071
)
Red blood cell count (
27863252
)
Temperament (bipolar disorder) (
22365631
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Interacting Genes
66 interacting genes:
ACAN
ADAMTSL2
ADAMTSL4
AK3
ALG10
APOA1
APP
ATN1
BHLHE40
CACNA1A
CCN2
CCN3
CHIC2
CREB5
CRIPTO
CXCL5
DDIAS
ECM1
EDC4
ELN
FGB
FN1
FXR1
GFI1B
HBEGF
HOXA1
HSPG2
ITGB1
KLHL20
KRTAP11-1
KRTAP19-2
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE3A
LCE5A
LINGO1
LMNTD2
LTBP4
MCPH1
MEOX2
MFAP5
MOB4
MRPL12
NEDD1
NID1
NLGN3
NOTCH3
NUFIP2
PAX5
PLSCR1
PPARA
SKIL
SLC66A2
SMAD3
SMAD4
SPRY1
TAF9
TANK
TCF7L2
TRIM42
UNKL
VCAN
YWHAQ
75 interacting genes:
ADAMTSL4
ALPP
CHIC2
CHRD
CRCT1
CREB5
CYSRT1
EFEMP1
EFEMP2
FBLN1
GUCD1
HOXA1
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP2-3
KRTAP2-4
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE4A
LCE5A
MACO1
NECTIN2
NTAQ1
NTN4
NUTF2
ODF1
OIT3
OTX1
PLA2G10
PLAC8
PLSCR3
PLSCR4
POU4F2
PSMB1
SLC39A7
SPRED2
SPRY1
SPRY2
TGFB1
TRIM42
VASN
VWC2
VWC2L
Entrez ID
2192
353133
HPRD ID
00629
13967
Ensembl ID
ENSG00000077942
ENSG00000197084
Uniprot IDs
A0A8S0LWY1
P23142
Q8NBH6
Q5T751
PDB IDs
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Tissue Development
Epidermis Development
Keratinization
Extracellular Matrix Structural Constituent
Developmental Process
Integrin Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of MiRNA Transcription
Regulation Of Signal Transduction
Response To Interleukin-1
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Regulation Of Intracellular Signal Transduction
Developmental Growth
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Endothelial Cell Migration
Negative Regulation Of Signal Transduction
Regulation Of MiRNA Metabolic Process
Angiogenesis
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of System Process
Anatomical Structure Formation Involved In Morphogenesis
Protein Binding
Negative Regulation Of Transcription By RNA Polymerase II
Animal Organ Development
Calcium-independent Cell-matrix Adhesion
Embryonic Pattern Specification
Adrenal Gland Development
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Identical Protein Binding
Extracellular Region
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Collagen Binding
Positive Regulation Of Cell-substrate Adhesion
Negative Regulation Of MiRNA Transcription
Cell Migration
Regulation Of Spontaneous Synaptic Transmission
Activin Receptor Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Intermediate Filament
Keratin Filament
Keratinization
Epidermis Development
Tissue Development
Hair Cycle
Negative Regulation Of Lens Fiber Cell Differentiation
Identical Protein Binding
Protein Binding
Regulation Of Lens Fiber Cell Differentiation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Branch Elongation Of An Epithelium
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Epithelial To Mesenchymal Transition
Axis Elongation
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Elastic Fiber
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Extracellular Matrix Assembly
Negative Regulation Of ERK1 And ERK2 Cascade
Bud Elongation Involved In Lung Branching
Interstitial Matrix
Regulation Of Cellular Response To Growth Factor Stimulus
Basement Membrane
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Tagcloud (Intersection)
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