HBEGF and REEP5

Data Source: HiPPIP (Novel)

		HBEGF	REEP5
Name		heparin binding EGF like growth factor	receptor accessory protein 5
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glycoprotein Biosynthetic Process Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of Wound Healing	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Endoplasmic Reticulum Membrane Organization
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	None
GWAS		Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Atrial fibrillation ( 28416822 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Creatine kinase levels ( 29403010 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) White matter integrity (fractional anisotropy) ( 32358547 ) White matter integrity (mean diffusivity) ( 32358547 )	Attention deficit hyperactivity disorder ( 18839057 ) Daytime nap ( 33568662 ) Reaction time ( 29844566 )
Novel Interactors		1 novel interactors: REEP5	9 novel interactors: CD14 CPOX EDC3 GPX3 HBEGF LGR5 PDK4 PDLIM3 TENT4A
Interacting Genes		12 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	13 interacting genes: ABHD4 ARFGAP1 ARFIP2 CHRM5 GTF2H1 NUDT3 PBX3 PITPNC1 RAB5B RABAC1 RGS2 SNX1 VKORC1
Entrez ID		1839	7905
HPRD ID		00526	15918
Ensembl ID		ENSG00000113070	ENSG00000129625
Uniprot IDs		Q99075	Q00765
PDB IDs		1XDT 2M8S	Not available
GO Terms Enriched among Interactors		Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Peptidase Activator Activity System Development Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Extracellular Region Cell Surface Regulation Of Locomotion Response To Growth Factor Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Integrin Binding Protein-containing Complex Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Extracellular Exosome Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Receptor Complex Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Fibroblast Proliferation Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Chondrocyte Differentiation	None