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HBEGF and MMP7
Number of citations of the paper that reports this interaction (PubMedID
11825873
)
55
Data Source:
HPRD
(in vivo)
HBEGF
MMP7
Description
heparin binding EGF like growth factor
matrix metallopeptidase 7
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Extracellular Region
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Molecular Function
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Receptor Ligand Activity
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Muscle Organ Development
Regulation Of Heart Contraction
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Glycoprotein Biosynthetic Process
Cell Migration
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Wound Healing, Spreading Of Epidermal Cells
ERBB2-EGFR Signaling Pathway
ERBB2-ERBB4 Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Positive Regulation Of Wound Healing
Antibacterial Peptide Secretion
Antibacterial Peptide Biosynthetic Process
Proteolysis
Membrane Protein Ectodomain Proteolysis
Response To Xenobiotic Stimulus
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Membrane Protein Intracellular Domain Proteolysis
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Pathways
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Uptake and function of diphtheria toxin
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 TMD/JMD mutants
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Extra-nuclear estrogen signaling
Drugs
Marimastat
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS
Alzheimer's disease (
28183528
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Atrial fibrillation (
28416822
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Creatine kinase levels (
29403010
)
General cognitive ability (
29844566
)
Intelligence (MTAG) (
29326435
)
White matter integrity (fractional anisotropy) (
32358547
)
White matter integrity (mean diffusivity) (
32358547
)
Blood protein levels (
30072576
)
Night sleep phenotypes (
27126917
)
Prostate cancer (
23535732
)
Prostate-specific antigen levels (
28139693
)
Interacting Genes
12 interacting genes:
APP
BAG1
CD44
CD82
CD9
EGFR
ERBB4
FBLN1
LTBP3
MMP7
NRDC
ZBTB16
16 interacting genes:
BCAN
CD151
CD44
DCN
FASLG
HAPLN1
HBEGF
MBP
MMP1
MMP9
NGF
PLG
SERPINA1
SPP1
TFPI
TNFSF11
Entrez ID
1839
4316
HPRD ID
00526
01525
Ensembl ID
ENSG00000113070
ENSG00000137673
Uniprot IDs
Q99075
P09237
PDB IDs
1XDT
2M8S
1MMP
1MMQ
1MMR
2DDY
2MZE
2MZH
2MZI
2Y6C
2Y6D
5UE2
5UE5
7WXX
8JUD
8JUF
8JUG
8K4Z
Enriched GO Terms of Interacting Partners
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Regulation Of ERK1 And ERK2 Cascade
Epidermal Growth Factor Receptor Activity
Epidermal Growth Factor Binding
Regulation Of Cell Population Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Peptidase Activator Activity
System Development
Regulation Of Cell Migration
Cellular Response To Growth Factor Stimulus
Regulation Of Cell Motility
Extracellular Region
Cell Surface
Regulation Of Locomotion
Response To Growth Factor
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of MAPK Cascade
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Population Proliferation
ERBB2 Signaling Pathway
Integrin Binding
Protein-containing Complex
Regulation Of Membrane Protein Ectodomain Proteolysis
Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Extracellular Exosome
Regulation Of Apoptotic Process
Anatomical Structure Morphogenesis
Receptor Complex
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Amyloid-beta Complex
Regulation Of Phosphorus Metabolic Process
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Extracellular Matrix Organization
Extracellular Structure Organization
Basolateral Plasma Membrane
Cellular Response To Epidermal Growth Factor Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Response To Epidermal Growth Factor
Multivesicular Body, Internal Vesicle Lumen
Establishment Of Planar Polarity Involved In Nephron Morphogenesis
Regulation Of Chondrocyte Differentiation
Extracellular Region
Extracellular Space
Extracellular Matrix
Cell Surface
Hyaluronic Acid Binding
Wound Healing, Spreading Of Cells
Extracellular Matrix Disassembly
Regulation Of Response To Wounding
Cellular Response To UV-A
Perineuronal Net
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Lipid Transport
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Positive Regulation Of Keratinocyte Migration
Response To UV-A
Positive Regulation Of Bone Resorption
Lysosomal Lumen
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Endopeptidase Activity
Regulation Of Cellular Component Organization
Cell Migration
Golgi Lumen
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Coagulation
Blood Coagulation
Protease Binding
Peptidase Inhibitor Activity
Hemostasis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Collateral Sprouting
System Development
Developmental Process
Cell Motility
Regulation Of Lipid Transport
Regulation Of Wound Healing
Positive Regulation Of Signal Transduction
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Tumor Necrosis Factor Receptor Binding
Central Nervous System Development
Extracellular Matrix Binding
Serine-type Endopeptidase Activity
Regulation Of Apoptotic Signaling Pathway
Signaling Receptor Binding
Positive Regulation Of ERBB Signaling Pathway
Regulation Of Bone Resorption
Collagen Catabolic Process
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Tagcloud (Intersection)
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