HBEGF and BAG1

Number of citations of the paper that reports this interaction (PubMedID 11340068)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		HBEGF	BAG1
Description		heparin binding EGF like growth factor	BAG cochaperone 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Adenyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glycoprotein Biosynthetic Process Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of Wound Healing	Protein Folding Apoptotic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Protein Stabilization
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Regulation of HSF1-mediated heat shock response
Drugs			(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416822) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Creatine kinase levels ( 29403010) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) White matter integrity (fractional anisotropy) ( 32358547) White matter integrity (mean diffusivity) ( 32358547)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		12 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	31 interacting genes: AR ARRB1 BCL2 BCL2L1 CEBPA ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 OGT PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 UBC VDR
Entrez ID		1839	573
HPRD ID		00526	03292
Ensembl ID		ENSG00000113070	ENSG00000107262
Uniprot IDs		Q99075	A0A0S2Z3K4 Q99933
PDB IDs		1XDT 2M8S	1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV
Enriched GO Terms of Interacting Partners?		Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Peptidase Activator Activity System Development Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Extracellular Region Cell Surface Regulation Of Locomotion Response To Growth Factor Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Integrin Binding Protein-containing Complex Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Extracellular Exosome Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Receptor Complex Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Fibroblast Proliferation Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Chondrocyte Differentiation	Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Macromolecule Metabolic Process Cytosol Ubiquitin Protein Ligase Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Signal Transduction Response To Hormone Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Apoptotic Process C3HC4-type RING Finger Domain Binding Positive Regulation Of Metabolic Process Signal Transduction Response To Steroid Hormone Identical Protein Binding Regulation Of Protein Modification Process ATP-dependent Protein Disaggregase Activity Cellular Response To Hormone Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Mitochondrion Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Biological Quality Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Microtubule Polymerization Cellular Response To Steroid Hormone Stimulus
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