FBLN1 and LTBP4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FBLN1	LTBP4
Gene Name		fibulin 1	latent transforming growth factor beta binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Extracellular Matrix Organization Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ	11 interactors: ATN1 ATXN7 CACNA1A CRKL CRY1 FBLN1 FRAT1 GFI1B ITSN2 RAC1 TGFB1
Entrez ID		2192	8425
HPRD ID		00629	05274
Ensembl ID		ENSG00000077942	ENSG00000090006
Uniprot IDs		P23142 Q8NBH6	B3KXY6 Q8N2S1
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Endocytosis Multicellular Organismal Development Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Bone Remodeling Positive Regulation Of Catalytic Activity Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Cellular Process Regulation Of Vesicle-mediated Transport Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Vestibular Nucleus Development Negative Regulation Of Glucocorticoid Secretion Blue Light Signaling Pathway Active Induction Of Host Immune Response By Virus Cell Death Death Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Kinase Activity Negative Regulation Of RNA Biosynthetic Process Tissue Remodeling Engulfment Of Apoptotic Cell Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Response To Blue Light Regulation Of Histone Modification Positive Regulation Of Behavior
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Intersection) ?