FBLN1 and MEOX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBLN1	MEOX2
Description		fibulin 1	mesenchyme homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Chromatin Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Angiogenesis Somite Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Roof Of Mouth Development Limb Development Somite Development Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Adolescent idiopathic scoliosis ( 31417091) Blood trace element (Zn levels) ( 23720494) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Kidney function decline traits ( 25493955) Resting-state electroencephalogram vigilance ( 29703947) Sweet taste preference ( 32572145) Total intracranial volume ( 31530798) Triglyceride levels ( 32203549)
Interacting Genes		66 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TRIM42 UNKL VCAN YWHAQ	686 interacting genes: - ABI2 ACBD4 ACOT12 ACSS1 ACTN4 ADAMTS12 ADGRF4 AGPAT1 AHCYL1 AHNAK AHSA2P AIRIM AKT2 ALOX5 ALPP AMMECR1 AMOT ANKRD1 ANKRD12 ANKS1A ANP32B ANXA2R-AS1 AP3M2 ARF6 ARHGEF7 ARIH2 ARL15 ARNT2 ASB10 ATG12 ATG2A ATG5 ATG9A ATP5F1C ATP6V0D2 ATP6V1C2 ATPSCKMT ATXN1L AXIN1 B4GALT2 BANP BCL2L15 BEX1 BMAL2 BMP5 BNIP2 BOD1L2 BOLA2 BOLA2B BTBD3 BTK BTN1A1 BUD31 BYSL C10orf120 C10orf88 C11orf68 C1orf174 C1orf50 C2orf76 CACNA1S CAMK2B CAPRIN2 CARD9 CASP14 CBX2 CCDC102B CCDC13 CCDC196 CCDC6 CCL19 CCNC CCNYL1 CDC34 CDC7 CDCA7L CDH9 CDK3 CDK5 CDKN1A CDKN2D CEP57L1 CFAP206 CHD2 CHIC2 CHRD CHRNB4 CHRNG CHST15 CIAO1 CIAPIN1 CIB3 CINP CKS1B CLIC1 CLIP4 CLP1 CLVS2 CMTM5 CNTNAP2 COG7 COL9A2 COMP COX7A2 CPNE2 CPNE6 CPNE7 CPSF4 CRCT1 CSDC2 CSF2 CSH2 CSNK2A1 CT55 CTNNBL1 CUTC CXCL1 CXCL5 CXorf38 CXXC1 CYB5R2 CYCS CYP4F12 CYSRT1 DCX DEF8 DEFA5 DEPDC5 DESI1 DGCR6 DGCR8 DHPS DIRAS3 DMRT3 DNAAF11 DNAAF19 DNAJC17 DNAJC22 DNMT3A DOCK8 DPF2 DPH3 DPM1 DRG1 DSCR8 DUS1L DYNC2I2 DYNLL2 DYNLT5 E2F8 EDF1 EFEMP1 EFEMP2 EFNA3 EIF1AD EIF3G EIF4A3 EIF5A EIF6 EMC7 EMD EME2 EPM2AIP1 ERF ESM1 ESR2 ESRRG ETV4 EXOSC5 FAAP20 FAM13C FAM200C FAM219B FAM221A FAM3A FAM53B FAM53C FAM74A4 FANCC FANCG FBF1 FBLN1 FBLN5 FBXO39 FBXO44 FDX2 FGA FKBP6 FOSL2 FOXR1 FTL FUCA2 FYN GABRB3 GAGE1 GARIN5B GCM2 GINS3 GJC1 GLO1 GMCL2 GMPR2 GNG11 GNG13 GOLGA8DP GOLGA8EP GOLGA8F GPANK1 GPATCH2L GPKOW GPSM3 GRIPAP1 GRN GSDMD GTPBP3 GUCD1 H1-7 HAT1 HDAC7 HDHD2 HELLS HEXIM2 HGF HK3 HLA-A HLA-DPB1 HMBOX1 HMGB3 HNRNPC HNRNPD HOOK1 HOOK3 HORMAD1 HOXB5 HOXC8 HP1BP3 HSD3B7 HSPA2 HTR1E HYCC1 IFIT2 IFNA14 IFNA6 IGF2BP3 IGFN1 IKZF1 IL1A ILF2 INPP1 INPP5J INSRR INTS10 IP6K2 IP6K3 IQGAP1 IRX6 ITGB3BP ITM2A JAM3 JPH1 KANK2 KAT5 KATNAL1 KBTBD7 KCNIP4 KCTD7 KCTD9 KDM6A KDM8 KIF5B KIF5C KIZ KLC4 KLHL32 KLHL38 KPRP KRT80 KRT81 KRT83 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KRTCAP3 KTN1 LAMTOR5 LARP1B LAT LCE1B LCE1D LCE1E LCE2A LCE4A LCN15 LEMD1 LIN37 LIPF LMO1 LNX1 LRRC18 LRRC27 LRRC52 LSM2 LUC7L2 LY6G6D MAB21L2 MACO1 MAGED1 MALSU1 MAPKBP1 MAPRE1 MAPRE3 MBD3 MCM7 MDFI METAP1 METTL17 METTL21A MFF MICOS10-NBL1 MID2 MKRN3 MLF1 MLLT6 MLX MMP25 MMP3 MOAP1 MOBP MORF4L1 MORF4L2 MORN3 MOS MPP1 MRFAP1L1 MSI2 MT-CO1 MT-ND1 MT1DP MTMR10 MVP MYBPC1 MYL7 MYO5B NAA10 NAA60 NALCN NBL1 NCALD NCK2 NCS1 NDUFA11 NDUFB2 NECTIN2 NEK6 NELL1 NFKBID NFYB NLGN3 NME7 NOL4 NOP10 NPIPB5 NR1D2 NSF NTAN1 NTF3 NTN4 ODAD4 ODF1 ODF2 ODF2L ODF4 OIT3 OLFM1 OLFM3 OR5K2 OR6B1 OSBPL1A OSGIN1 OSTF1 P4HA3 PACSIN2 PAGE2 PAGE5 PAK1IP1 PAM16 PARP3 PARVG PAX1 PAX3 PCDH9 PCSK5 PDE4C PDHA2 PDP1 PDS5A PELO PGBD1 PHF1 PICK1 PIN1 PKIG PLAC8 PLCB4 PLCD4 PMM2 PMS2 PNKP PNLIPRP1 POFUT4 POLR1A POLR1C POLR3GL POM121C POMT1 PPP1CB PPP1R18 PRAP1 PRKAB2 PRKAG1 PRKCI PRKG1 PRKN PRL PRMT3 PRPF18 PRPF31 PRR19 PSMB10 PSMB8 PSMC1 PSMD14 PSMD9 PSME3 PTGER3 PWWP3A PXT1 QNG1 RAB11B RAB2B RAB41 RAB6B RAD51B RAD51D RAD52 RAP1GAP2 RARB RASAL2 RBM10 RBM5 RBPJL RCHY1 RECK RELA RFTN2 RFX3 RGS5 RHOJ RIMS3 RIPPLY1 RMND5A RND2 RNF25 RNF40 RNF41 RNF6 RPL15 RPL23 RPP40 RPS4Y1 RRP8 RUNX1T1 RWDD2B SAE1 SAMD4A SAMM50 SAT1 SATB1 SCAF1 SCARF1 SCG5 SCIMP SCNM1 SCRN2 SDCBP SEC14L4 SEC63 SELENOP SET SFTPB SH2D1B SH2D4A SHFL SHISA3 SIRPB1 SKP1 SLC22A23 SLC23A1 SLC24A5 SLC25A17 SLC25A31 SLC27A5 SLC48A1 SLC66A1LP SLC9A8 SLIT1 SMAD3 SMARCE1 SMG6 SMYD1 SNRPF SPANXN2 SPANXN3 SPATA1 SPEG SPON1 SPP1 SPRED1 SPRY1 SPRY2 SPRY3 SPTY2D1 SRSF11 SSX3 STAC STC1 STK11IP STK16 STRA8 STX11 STX16 STX6 STXBP1 SUFU SUSD4 SYNE2 SYT17 TAF1B TASOR2 TBC1D21 TBCEL TBL2 TBRG4 TBX6 TCEA2 TCEANC TCL6 TDO2 TEX14 TEX47 TGFB1 THRA TICAM2 TJAP1 TMEM100 TMEM14B TMEM266 TMPRSS11E TNPO3 TP53BP1 TPTE TRAF5 TRAF6 TRAPPC2L TRARG1 TRIM17 TRIM41 TRIM42 TRIM45 TRIM50 TRIML2 TRIP10 TRMT112 TRMT2A TSGA10IP TSPAN7 TSPO TSR2 TSSK1B TSTD2 TTC39B TTC9C TTLL10 TULP2 TXLNA TXLNB TXN2 TXNL4B U2AF1 UBA2 UBE2D1 UBE2K UBE3A UBL4A UBL4B UBXN2B UBXN8 UNC45A UPP2 USE1 USP20 USP32 UTP14C UTP23 UTP25 VAC14 VASN VBP1 VCX2 VDR VEZF1 VIP VMP1 VPS26C VWA5A VWC2L VWCE WDR37 WDR5 WFDC13 WFDC5 WFDC6 WFDC9 XPA XRCC2 YJU2 ZBED4 ZBTB16 ZBTB2 ZCWPW1 ZFP42 ZKSCAN3 ZKSCAN4 ZMAT2 ZMYND8 ZNF124 ZNF202 ZNF23 ZNF248 ZNF250 ZNF276 ZNF329 ZNF330 ZNF404 ZNF410 ZNF417 ZNF483 ZNF490 ZNF512B ZNF556 ZNF564 ZNF572 ZNF574 ZNF587 ZNF648 ZNF688 ZNF69 ZNF695 ZNF772 ZNF92
Entrez ID		2192	4223
HPRD ID		00629	02760
Ensembl ID		ENSG00000077942	ENSG00000106511
Uniprot IDs		A0A8S0LWY1 P23142 Q8NBH6	P50222
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process	Protein Binding Intermediate Filament Keratin Filament Identical Protein Binding Hair Cycle
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