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FBLN1 and HSPG2
Number of citations of the paper that reports this interaction (PubMedID
7500359
)
0
Data Source:
HPRD
(in vitro)
FBLN1
HSPG2
Description
fibulin 1
heparan sulfate proteoglycan 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Region
Basement Membrane
Extracellular Space
Golgi Lumen
Plasma Membrane
Focal Adhesion
Extracellular Matrix
Neuron Projection
Lysosomal Lumen
Extracellular Exosome
Plasma Membrane Protein Complex
Molecular Function
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Peptidase Activator Activity
Identical Protein Binding
Protein-containing Complex Binding
Fibrinogen Binding
Amyloid-beta Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Metal Ion Binding
Low-density Lipoprotein Particle Receptor Binding
Collagen V Binding
Biological Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Integrin-mediated Signaling Pathway
Embryo Implantation
Positive Regulation Of Gene Expression
Extracellular Matrix Organization
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Transformation Of Host Cell By Virus
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Cell Motility
Negative Regulation Of Stem Cell Proliferation
Angiogenesis
Response To Hypoxia
Positive Regulation Of Endothelial Cell Proliferation
Lipid Metabolic Process
Receptor-mediated Endocytosis
Inflammatory Response
Negative Regulation Of Cell Adhesion
Smoothened Signaling Pathway
Brain Development
Embryo Implantation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Negative Regulation Of Angiogenesis
Cell Differentiation
Animal Organ Regeneration
Negative Regulation Of Neuron Apoptotic Process
Circulatory System Development
Negative Regulation Of Amyloid Fibril Formation
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Glycosaminoglycan-protein linkage region biosynthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Attachment and Entry
Attachment and Entry
Retinoid metabolism and transport
Amyloid fiber formation
Respiratory syncytial virus (RSV) attachment and entry
RSV-host interactions
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Palifermin
Diseases
Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS
Blood protein levels (
30072576
)
Colon cancer (
33632709
)
Distal colorectal cancer (
33632709
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Low density lipoprotein cholesterol levels (
32154731
)
Paneth cell defects in Crohn's disease (
28352666
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
QT interval (
29213071
)
Red blood cell count (
27863252
)
Temperament (bipolar disorder) (
22365631
)
Atrial fibrillation (
30061737
)
Cerebral microbleeds (lobar) (
32913026
)
Height (
28552196
)
PR interval (
32439900
)
Interacting Genes
66 interacting genes:
ACAN
ADAMTSL2
ADAMTSL4
AK3
ALG10
APOA1
APP
ATN1
BHLHE40
CACNA1A
CCN2
CCN3
CHIC2
CREB5
CRIPTO
CXCL5
DDIAS
ECM1
EDC4
ELN
FGB
FN1
FXR1
GFI1B
HBEGF
HOXA1
HSPG2
ITGB1
KLHL20
KRTAP11-1
KRTAP19-2
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE3A
LCE5A
LINGO1
LMNTD2
LTBP4
MCPH1
MEOX2
MFAP5
MOB4
MRPL12
NEDD1
NID1
NLGN3
NOTCH3
NUFIP2
PAX5
PLSCR1
PPARA
SKIL
SLC66A2
SMAD3
SMAD4
SPRY1
TAF9
TANK
TCF7L2
TRIM42
UNKL
VCAN
YWHAQ
33 interacting genes:
APP
ATF7IP
ATN1
BMP1
CACNA1A
CCN2
COL13A1
ECM1
FBLN1
FBLN2
FBN1
FGF2
FGF7
FGFBP1
FN1
GFI1B
GRN
HSP90AA1
ITGA2
ITGB1
LAMA1
MTDH
NID1
NID2
PDGFA
PDGFB
PRELP
PRPF40A
SPARC
TCAP
TTR
UBC
VWA1
Entrez ID
2192
3339
HPRD ID
00629
00804
Ensembl ID
ENSG00000077942
ENSG00000142798
Uniprot IDs
A0A8S0LWY1
P23142
Q8NBH6
P98160
PDB IDs
3SH4
3SH5
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Tissue Development
Epidermis Development
Keratinization
Extracellular Matrix Structural Constituent
Developmental Process
Integrin Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of MiRNA Transcription
Regulation Of Signal Transduction
Response To Interleukin-1
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Regulation Of Intracellular Signal Transduction
Developmental Growth
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Endothelial Cell Migration
Negative Regulation Of Signal Transduction
Regulation Of MiRNA Metabolic Process
Angiogenesis
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Extracellular Matrix Organization
Extracellular Structure Organization
Cell-matrix Adhesion
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of System Process
Anatomical Structure Formation Involved In Morphogenesis
Protein Binding
Negative Regulation Of Transcription By RNA Polymerase II
Animal Organ Development
Calcium-independent Cell-matrix Adhesion
Embryonic Pattern Specification
Adrenal Gland Development
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Identical Protein Binding
Extracellular Region
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Collagen Binding
Positive Regulation Of Cell-substrate Adhesion
Negative Regulation Of MiRNA Transcription
Cell Migration
Regulation Of Spontaneous Synaptic Transmission
Activin Receptor Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Extracellular Matrix Structural Constituent
Extracellular Matrix
Extracellular Region
Extracellular Space
Basement Membrane
Heparin Binding
Collagen Binding
Positive Regulation Of Cell Migration
Integrin Binding
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Cell-matrix Adhesion
Regulation Of Cell Motility
Regulation Of Locomotion
Cell-substrate Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet Alpha Granule Lumen
Regulation Of Endothelial Cell Proliferation
Chemoattractant Activity
Growth Factor Activity
Peptidase Activator Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Endoplasmic Reticulum Lumen
Integrin-mediated Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Positive Chemotaxis
Positive Regulation Of Cell Communication
Positive Regulation Of Epithelial Cell Proliferation
Response To Wounding
Positive Regulation Of Endothelial Cell Migration
Cell Adhesion
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Developmental Process
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Epithelial Cell Proliferation
Animal Organ Development
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Tagcloud (Intersection)
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