HBEGF and LTBP3

Number of citations of the paper that reports this interaction (PMID 11846885)
3

Data Source:
HPRD (two hybrid)

		HBEGF	LTBP3
Gene Name		heparin-binding EGF-like growth factor	latent transforming growth factor beta binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Calcium Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Wound Healing	Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling EGFR Transactivation by Gastrin PI3K/AKT activation Uptake and actions of bacterial toxins PI-3K cascade GRB2 events in ERBB2 signaling Gastrin-CREB signalling pathway via PKC and MAPK PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Uptake and function of diphtheria toxin	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Urate levels ( 23263486)
Protein-Protein Interactions		11 interactors: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRD1 ZBTB16	12 interactors: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3
Entrez ID		1839	4054
HPRD ID		00526	03649
Ensembl ID		ENSG00000113070	ENSG00000168056
Uniprot IDs		Q99075	B9EG76 Q8WYU6 Q9NS15
PDB IDs		1XDT
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Single Organism Reproductive Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Regulation Of Protein Metabolic Process Secretion Positive Regulation Of Metabolic Process Reproductive Process Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Regulation Of Cell Death Developmental Process Cell Migration Cell Motility System Development Negative Regulation Of Apoptotic Process Regulation Of Chondrocyte Differentiation Negative Regulation Of Programmed Cell Death Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Mesenchymal Stem Cell Proliferation Transforming Growth Factor Beta Activation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Death Regulation Of Cellular Amino Acid Metabolic Process Organ Development Programmed Cell Death Regulation Of Peptidase Activity Embryonic Pattern Specification Regulation Of Cartilage Development Cell Death Death Regulation Of Protein Phosphorylation	Negative Regulation Of Macrophage Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Import Into Nucleus Cell Growth Regulation Of Cell Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Wound Healing Uterine Wall Breakdown Tissue Remodeling Response To Wounding Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Signaling Pathway Face Morphogenesis Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Head Morphogenesis Head Development Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Ossification Involved In Bone Remodeling Hemostasis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Salivary Gland Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Salivary Gland Development Cell Surface Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Transforming Growth Factor Beta Platelet Activation Frontal Suture Morphogenesis Response To Progesterone Regulation Of Phosphorus Metabolic Process Face Development Cell Motility Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth SMAD Protein Signal Transduction Negative Regulation Of Cytokine Production Regulation Of Epithelial To Mesenchymal Transition Cell-cell Junction Organization Regulation Of Lipid Kinase Activity Bone Remodeling Exocrine System Development Body Morphogenesis
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Intersection) ?