HBEGF and LTBP3

Number of citations: 52 (PubMedID 11846885)
Data Source: HPRD (two hybrid)

		HBEGF	LTBP3
Name		heparin binding EGF like growth factor	latent transforming growth factor beta binding protein 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Extracellular Matrix Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glycoprotein Biosynthetic Process Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of Wound Healing	Skeletal System Development Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Diseases		None	Tooth agenesis; Hypodontia
GWAS		Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Atrial fibrillation ( 28416822 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Creatine kinase levels ( 29403010 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) White matter integrity (fractional anisotropy) ( 32358547 ) White matter integrity (mean diffusivity) ( 32358547 )	Acne (severe) ( 24927181 ) Eosinophil count ( 32888494 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Lymphocyte count ( 32888494 ) Non-alcoholic fatty liver disease histology (lobular) ( 20708005 ) Osteoarthritis (hip) ( 30374069 ) Refractive error ( 32231278 ) Serum alkaline phosphatase levels ( 33547301 ) Urate levels ( 23263486 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		12 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	17 interacting genes: CACNA1A CCNG1 DYRK1A GORASP2 HBEGF HOXA1 ITGB5 MBD1 NUFIP2 PELI2 PIK3R2 PRPF40A RAC1 SHANK3 TGFB1 TGFB2 TGFB3
Entrez ID		1839	4054
HPRD ID		00526	03649
Ensembl ID		ENSG00000113070	ENSG00000168056
Uniprot IDs		Q99075	B9EG76 Q8WYU6 Q9NS15
PDB IDs		1XDT 2M8S	Not available
GO Terms Enriched among Interactors		Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Peptidase Activator Activity System Development Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Extracellular Region Cell Surface Regulation Of Locomotion Response To Growth Factor Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Integrin Binding Protein-containing Complex Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Extracellular Exosome Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Receptor Complex Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Fibroblast Proliferation Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Chondrocyte Differentiation	Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Regulation Of Cytoskeleton Organization Transforming Growth Factor Beta Receptor Binding Regulation Of Actin Cytoskeleton Organization Uterine Wall Breakdown Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Gland Morphogenesis Positive Regulation Of Protein Transport Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Secretion Growth Factor Activity Inner Ear Development Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Platelet Alpha Granule Lumen Regulation Of Interleukin-23 Production Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Transport Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Localization Cell Junction Organization Secondary Palate Development Regulation Of Organelle Organization Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Cell Division Positive Regulation Of Cardiocyte Differentiation Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Nucleus Odontogenesis Regulation Of Establishment Of Protein Localization Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway