HBEGF and NRDC

Number of citations: 48 (PubMedID 11432822)
Data Source: HPRD (in vitro, in vivo)

		HBEGF	NRDC
Name		heparin binding EGF like growth factor	nardilysin convertase
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Mitochondrion Mitochondrial Matrix Cytosol Cell Surface Dendrite Cell Projection
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Epidermal Growth Factor Binding Endopeptidase Activator Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glycoprotein Biosynthetic Process Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of Wound Healing	Proteolysis Positive Regulation Of Myelination Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Axonogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	None
GWAS		Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Atrial fibrillation ( 28416822 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Creatine kinase levels ( 29403010 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) White matter integrity (fractional anisotropy) ( 32358547 ) White matter integrity (mean diffusivity) ( 32358547 )	Appendicular lean mass ( 33097823 )
Interacting Genes		12 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC
Entrez ID		1839	4898
HPRD ID		00526	04036
Ensembl ID		ENSG00000113070	ENSG00000078618
Uniprot IDs		Q99075	G3V1R5 O43847 Q6UUU9
PDB IDs		1XDT 2M8S	Not available
GO Terms Enriched among Interactors		Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Peptidase Activator Activity System Development Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Extracellular Region Cell Surface Regulation Of Locomotion Response To Growth Factor Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Integrin Binding Protein-containing Complex Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Extracellular Exosome Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Receptor Complex Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Fibroblast Proliferation Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Chondrocyte Differentiation	Cell-cell Signaling Cell Communication Signaling Neuronal Dense Core Vesicle Hippocampal Mossy Fiber To CA3 Synapse Regulation Of System Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Oxytocin Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Amylin Receptor 1 Signaling Pathway Calcitonin Receptor Binding Signaling Receptor Binding Endocytosis Amylin Receptor 2 Signaling Pathway Hormone Activity Insulin Receptor Complex Neuropeptide Signaling Pathway Opioid Receptor Binding Opioid Peptide Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Asymmetric, Glutamatergic, Excitatory Synapse Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse