FBLN1 and EDC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FBLN1	EDC4
Gene Name		fibulin 1	enhancer of mRNA decapping 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity	Protein Binding
	Biological Process	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Molecules associated with elastic fibres Elastic fibre formation	mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)	Coronary heart disease ( 21347282) Metabolic syndrome ( 22399527)
Protein-Protein Interactions		35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ	5 interactors: CCL5 EIF2AK2 FBLN1 GIT2 YTHDC1
Entrez ID		2192	23644
HPRD ID		00629	06911
Ensembl ID		ENSG00000077942	ENSG00000038358
Uniprot IDs		P23142 Q8NBH6	Q6P2E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Negative Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Catalytic Activity Regulation Of Translational Initiation Negative Regulation Of Viral Process Evasion Or Tolerance By Virus Of Host Immune Response Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Viral Process Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Hydrolase Activity Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Virus Positive Regulation Of Protein Metabolic Process Regulation Of Translation Positive Regulation Of Activation Of Janus Kinase Activity Response To Host Immune Response Positive Regulation Of Macrophage Chemotaxis Regulation Of NLRP3 Inflammasome Complex Assembly Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Osteoblast Proliferation Modulation By Virus Of Host Process Regulation Of Chronic Inflammatory Response Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Activation Of Phospholipase D Activity Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Regulation Of Translation In Response To Stress Response To Interferon-alpha Posttranscriptional Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Intersection) ?