FBLN1 and NOV

Number of citations of the paper that reports this interaction (PMID 9927660)
41

Data Source:
HPRD (two hybrid, in vitro)

		FBLN1	NOV
Gene Name		fibulin 1	nephroblastoma overexpressed
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Axon Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity	Integrin Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding
	Biological Process	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Regulation Of Gene Expression Negative Regulation Of Cell Death
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs			Insulin Regular Insulin, porcine
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)	Blood pressure ( 21909110) Hypertension ( 21626137)
Protein-Protein Interactions		35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ	14 interactors: ADSL CDKN1A CTGF DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4
Entrez ID		2192	4856
HPRD ID		00629	01291
Ensembl ID		ENSG00000077942	ENSG00000136999
Uniprot IDs		P23142 Q8NBH6	P48745
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Response To Wounding Wound Healing Regulation Of Growth Regulation Of Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Developmental Process Tissue Development Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cellular Component Organization Cardiovascular System Development Multicellular Organismal Development Vasculature Development Anatomical Structure Development Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glycogen Metabolic Process Anatomical Structure Morphogenesis Digestive System Development Tube Development Positive Regulation Of Mitotic Nuclear Division Response To Stress Compartment Pattern Specification Blood Vessel Morphogenesis Tissue Regeneration Response To Organonitrogen Compound Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Heart Looping Response To Peptide Regulation Of Cell Cycle Process Enzyme Linked Receptor Protein Signaling Pathway Determination Of Heart Left/right Asymmetry Secretion By Cell Blood Vessel Development Embryonic Heart Tube Morphogenesis Organ Development
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	autologous avian chicken cloned conserved element elements elevated encodes homolog igfii interrelated inversely kidney might nephroblastomas novh oncogene overexpressed predominantly proto putative relative represent sequenced stromal tumors wilms wt1
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	autologous avian chicken cloned conserved element elements elevated encodes homolog igfii interrelated inversely kidney might nephroblastomas novh oncogene overexpressed predominantly proto putative relative represent sequenced stromal tumors wilms wt1
Tagcloud (Intersection) ?