FBLN1 and TDGF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FBLN1	TDGF1
Gene Name		fibulin 1	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity	Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization	Activation Of MAPK Activity Vasculogenesis In Utero Embryonic Development Morphogenesis Of A Branching Structure Positive Regulation Of Cell-matrix Adhesion Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Gastrulation Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Somatic Stem Cell Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Transcriptional regulation of pluripotent stem cells Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by NODAL
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ	10 interactors: ACVR1B ACVR1C ANG AP2S1 BAG6 COPS6 FARSA FBLN1 GDF9 LRIF1
Entrez ID		2192	6997
HPRD ID		00629	01757
Ensembl ID		ENSG00000077942	ENSG00000241186
Uniprot IDs		P23142 Q8NBH6	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Nodal Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Reproductive Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Oogenesis Negative Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Trophoblast Cell Migration Oocyte Growth Female Gamete Generation Single Organism Reproductive Process Development Of Primary Female Sexual Characteristics Regulation Of Chorionic Trophoblast Cell Proliferation Negative Regulation Of Trophoblast Cell Migration Viral Process Positive Regulation Of Peptidase Activity Diacylglycerol Biosynthetic Process Phenylalanyl-tRNA Aminoacylation Activation Of Phospholipase A2 Activity Regulation Of Progesterone Secretion Negative Regulation Of Cell Growth Regulation Of Secretion Positive Regulation Of Phospholipase A2 Activity Gamete Generation Developmental Process Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Insertion Into ER Membrane Cullin Deneddylation Sexual Reproduction Multicellular Organismal Reproductive Process Development Of Primary Sexual Characteristics Multicellular Organism Reproduction Negative Regulation Of Growth Positive Regulation Of Phosphorylation Protein Deneddylation Germ Cell Development
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Intersection) ?