FBLN1 and NEDD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FBLN1	NEDD1
Description		fibulin 1	NEDD1 gamma-tubulin ring complex targeting factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Pericentriolar Material Spindle Pole Fibrillar Center Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Basal Body Apical Part Of Cell
	Molecular Function	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Mitotic Cell Cycle Microtubule Nucleation Cell Division
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Adventurousness ( 30643258) Autism ( 24189344) Breast size ( 22747683) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Manganese levels ( 26025379) Obstructive sleep apnea (BMI adjusted) ( 33243845)
Interacting Genes		66 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TRIM42 UNKL VCAN YWHAQ	6 interacting genes: CDK1 CEBPA EP300 FBLN1 PLK1 RND1
Entrez ID		2192	121441
HPRD ID		00629	02655
Ensembl ID		ENSG00000077942	ENSG00000139350
Uniprot IDs		A0A8S0LWY1 P23142 Q8NBH6	A8K1Z3 Q8NHV4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process	Mitotic Nuclear Membrane Disassembly Protein Localization To Chromosome Positive Regulation Of Protein Localization To Nucleus STAT Family Protein Binding Membrane Disassembly Nuclear Membrane Disassembly Regulation Of Protein Localization To Nucleus Protein Localization To Site Of Double-strand Break Negative Regulation Of Stem Cell Proliferation Mitotic G2 DNA Damage Checkpoint Signaling Intracellular Signal Transduction Spindle Microtubule Chromosome Condensation Intracellular Signaling Cassette Positive Regulation Of Protein Import Into Nucleus Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromatin Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Import Into Nucleus Protein Destabilization Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Positive Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Protein Localization Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Microtubule Organizing Center Organization Regulation Of Stem Cell Proliferation Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding
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