HBEGF and CD9

Number of citations: 52 (PubMedID 11846885)
Data Source: HPRD (in vivo, two hybrid)

		HBEGF	CD9
Name		heparin binding EGF like growth factor	CD9 molecule
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Integrin Binding Protein Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glycoprotein Biosynthetic Process Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of Wound Healing	Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Cell Differentiation Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs		None	C31G
GWAS		Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Atrial fibrillation ( 28416822 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Creatine kinase levels ( 29403010 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) White matter integrity (fractional anisotropy) ( 32358547 ) White matter integrity (mean diffusivity) ( 32358547 )	Colorectal cancer ( 24836286 ) Colorectal cancer or advanced adenoma ( 30510241 ) Mean platelet volume ( 22139419 27863252 32888494 ) Paclitaxel-induced neuropathy ( 23776197 ) Platelet count ( 22139419 26805783 )
Interacting Genes		12 interacting genes: APP BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRDC ZBTB16	25 interacting genes: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT ODF4 PRKCA PTGFRN SERPINH1 SLC22A1 SLC22A2 TSPAN4 VKORC1
Entrez ID		1839	928
HPRD ID		00526	00880
Ensembl ID		ENSG00000113070	ENSG00000010278
Uniprot IDs		Q99075	A0A087WU13 A6NNI4 B4DK09 G8JLH6 P21926
PDB IDs		1XDT 2M8S	6K4J 6RLO 6RLR 6Z1V 6Z20
GO Terms Enriched among Interactors		Regulation Of ERK1 And ERK2 Cascade Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Peptidase Activator Activity System Development Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Extracellular Region Cell Surface Regulation Of Locomotion Response To Growth Factor Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Integrin Binding Protein-containing Complex Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Extracellular Exosome Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Receptor Complex Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Fibroblast Proliferation Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Chondrocyte Differentiation	Cell Surface Integrin Binding Membrane Plasma Membrane External Side Of Plasma Membrane System Process Integrin Complex Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Learning Or Memory Regulation Of Locomotion Developmental Process Cognition Cell-matrix Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Protein-containing Complex Binding Regulation Of Multicellular Organismal Process Regulation Of System Process Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Pyrimidine Nucleoside Transmembrane Transporter Activity Vascular Process In Circulatory System Focal Adhesion Import Into Cell Regulation Of Epithelial Cell Migration Neurotransmitter Reuptake Laminin Binding Cell Adhesion Cell-substrate Adhesion Positive Regulation Of Signaling Myoblast Fusion Involved In Skeletal Muscle Regeneration Integrin Alpha2-beta1 Complex Putrescine Transmembrane Transporter Activity Virus Receptor Activity Circulatory System Process Regulation Of Biological Quality Positive Regulation Of Protein Localization To Membrane Myoblast Fusion Cell Adhesion Mediated By Integrin Positive Regulation Of Signal Transduction Receptor Complex Wound Healing, Spreading Of Cells Neurotransmitter Uptake Response To Muscle Activity