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HBEGF
Gene Name
heparin-binding EGF-like growth factor
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
Epidermal Growth Factor Receptor Binding
Growth Factor Activity
Heparin Binding
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Muscle Organ Development
Regulation Of Heart Contraction
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Wound Healing, Spreading Of Epidermal Cells
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Elastin Biosynthetic Process
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Wound Healing
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
EGFR Transactivation by Gastrin
PI3K/AKT activation
Uptake and actions of bacterial toxins
PI-3K cascade
GRB2 events in ERBB2 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Nuclear signaling by ERBB4
SHC1 events in ERBB4 signaling
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS
Protein-protein Interactions
11 interactors:
BAG1
CD44
CD82
CD9
EGFR
ERBB4
FBLN1
LTBP3
MMP7
NRD1
ZBTB16
Entrez ID
1839
HPRD ID
00526
Ensembl ID
ENSG00000113070
Uniprot IDs
Q99075
PDB IDs
1XDT
Enriched GO Terms of Interacting Partners
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Regulation Of Cell Proliferation
Extracellular Matrix Organization
Extracellular Structure Organization
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Response To Fibroblast Growth Factor
Single Organism Reproductive Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Protein Metabolic Process
Response To Growth Factor
Regulation Of Peptidyl-tyrosine Phosphorylation
Multicellular Organismal Development
Regulation Of Protein Metabolic Process
Secretion
Positive Regulation Of Metabolic Process
Reproductive Process
Anatomical Structure Morphogenesis
Regulation Of Apoptotic Process
Movement Of Cell Or Subcellular Component
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Developmental Process
Cell Migration
Cell Motility
System Development
Negative Regulation Of Apoptotic Process
Regulation Of Chondrocyte Differentiation
Negative Regulation Of Programmed Cell Death
Alkanesulfonate Metabolic Process
Cardiac Muscle Tissue Regeneration
Antibacterial Peptide Secretion
Antibacterial Peptide Biosynthetic Process
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Transforming Growth Factor Beta Activation
Apoptotic Process
Central Nervous System Development
Negative Regulation Of Cell Death
Regulation Of Cellular Amino Acid Metabolic Process
Organ Development
Programmed Cell Death
Regulation Of Peptidase Activity
Embryonic Pattern Specification
Regulation Of Cartilage Development
Cell Death
Death
Regulation Of Protein Phosphorylation
Tagcloud
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amphiregulin
areg
betacellulin
btc
calgb
cd73
cetuximab
chemo
dusp4
epgn
epigen
epiregulin
erbb3
erbb4
ereg
folfiri
folfox
formalin
her3
her4
implicate
kras
mcrc
modeled
multiplicative
nt5e
pfs
phlda1
tgfa