DDOST and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		DDOST	LTB4R2
Description		dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	leukotriene B4 receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		7 interacting genes: ISG15 LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		1650	56413
HPRD ID		03728	16153
Ensembl ID		ENSG00000244038	ENSG00000213906
Uniprot IDs		P39656	B4E292 Q9NPC1
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Septin Cytoskeleton Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Leukotriene B4 Receptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Type I Interferon Production Leukotriene Receptor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Protein Oligomerization Leukotriene Signaling Pathway	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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