DDOST and NXT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DDOST	NXT1
Gene Name		dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)	nuclear transport factor 2-like export factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex	Nuclear Pore Cytoplasm Nuclear Speck
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	Protein Binding Ran GTPase Binding
	Biological Process	Translation Protein Glycosylation Protein N-linked Glycosylation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Cytokine T Cell Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response	RNA Export From Nucleus Protein Export From Nucleus
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Translation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 SRP-dependent cotranslational protein targeting to membrane Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: MAPK6 NXT1 SRSF11 TMEM173	8 interactors: DDOST NXF1 NXF2 NXF3 PAXIP1 RAN STAU1 XPO1
Entrez ID		1650	29107
HPRD ID		03728	16159
Ensembl ID		ENSG00000244038	ENSG00000132661
Uniprot IDs		E7EWT1 P39656	Q9UKK6
PDB IDs			1JKG 1JN5
Enriched GO Terms of Interacting Partners?		RNA Export From Nucleus Nuclear Export RNA Transport RNA Localization Interferon-beta Production Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Cytoplasmic Transport Regulation Of Defense Response To Virus By Host Cellular Response To DsRNA Protein Export From Nucleus Positive Regulation Of Transcription Factor Import Into Nucleus Termination Of RNA Polymerase II Transcription	Nuclear Export RNA Localization Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport MRNA Transport RNA Transport Ribosomal Small Subunit Export From Nucleus Cellular Localization MRNA Export From Nucleus RNA Export From Nucleus Intracellular Transport Ribosomal Large Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Poly(A)+ MRNA Export From Nucleus Establishment Of Localization In Cell Gene Expression Intracellular Transport Of Virus Protein Export From Nucleus Positive Regulation Of Histone H3-K36 Methylation Protein Localization To Organelle Viral Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Protein Localization To Nucleus Transport Ribosome Biogenesis Viral Life Cycle Intracellular Protein Transport Chorion Development Intracellular MRNA Localization Cellular Protein Complex Localization Ribonucleoprotein Complex Biogenesis Establishment Of Organelle Localization Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Establishment Of Protein Localization To Organelle Positive Regulation Of DNA-templated Transcription, Initiation Protein Complex Localization Positive Regulation Of Histone Acetylation Positive Regulation Of Viral Genome Replication Regulation Of DNA-templated Transcription, Initiation Regulation Of Histone H3-K4 Methylation Cellular Protein Localization Organelle Localization Protein Targeting Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Acetylation Protein Transport
Tagcloud ?		3xflag atp5c1 compatible created creating deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?