DDOST and STING1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		DDOST	STING1
Description		dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	stimulator of interferon response cGAMP interactor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Golgi Membrane Autophagosome Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex STING Complex
	Molecular Function	Protein Binding Enzyme Activator Activity	Nucleotide Binding Transcription Coactivator Activity Protein Binding Proton Channel Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity 2',3'-cyclic GMP-AMP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine/threonine Kinase Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation	Autophagosome Assembly Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Monoatomic Ion Transport Autophagy Regulation Of Gene Expression Positive Regulation Of Macroautophagy Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interferon-beta Production Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Protein Complex Oligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Reticulophagy Protein Localization To Endoplasmic Reticulum Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Proton Transmembrane Transport
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		7 interacting genes: ISG15 LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1	26 interacting genes: CCDC47 CCDC50 CMTM5 DDOST IFI16 IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 MYSM1 PLLP REEP6 RNF115 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM10 USP20 USP35 USP49 YIPF2
Entrez ID		1650	340061
HPRD ID		03728	14173
Ensembl ID		ENSG00000244038	ENSG00000184584
Uniprot IDs		P39656	A0A494C0W5 J3QTB1 Q86WV6 V5V0K2
PDB IDs		6S7O 6S7T 8B6L 8PN9	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XF3 6XF4 6XNP 6Y99 6YDB 6YDZ 6YEA 6YWA 6YWB 6Z0Z 6Z15 7A90 7KVX 7KVZ 7KW1 7MHC 7OB3 7Q3B 7Q85 7R4H 7SHO 7SHP 7SII 7SSM 7T9U 7T9V 7X9P 7X9Q 7ZKU 7ZV0 7ZVK 7ZWL 7ZXB 8A2H 8A2I 8A2J 8A2K 8A2X 8B2J 8FLK 8FLM 8GJX 8GSZ 8GT6 8IK3 8ORW 8P45 8STH 8STI 8T5K 8T5L 9IJN
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Septin Cytoskeleton Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Leukotriene B4 Receptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Type I Interferon Production Leukotriene Receptor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Protein Oligomerization Leukotriene Signaling Pathway	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex Post-translational Protein Modification Protein Modification Process Early Endosome To Golgi Transport Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein N-linked Glycosylation Via Asparagine
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