DDOST and SRSF11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DDOST	SRSF11
Description		dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	serine and arginine rich splicing factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Protein Binding Enzyme Activator Activity	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation	MRNA Processing RNA Splicing
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		7 interacting genes: ISG15 LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1	33 interacting genes: ARL6IP4 ATP5F1D CDK6 CSNK2A1 DACH1 DDOST DUSP29 ETS1 GATC HNRNPLL HYI LNX2 MDM2 MEOX2 OGT PAK5 PAX6 PIN1 PUF60 RAB2B RNPS1 SDCBP SREK1 SRPK2 SRRM4 SRSF1 SRSF2 TANK THAP11 TOP1 U2AF2 ZC3HAV1 ZNF385C
Entrez ID		1650	9295
HPRD ID		03728	03599
Ensembl ID		ENSG00000244038	ENSG00000116754
Uniprot IDs		P39656	Q05519 Q5T757 Q5T760
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Septin Cytoskeleton Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Leukotriene B4 Receptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Type I Interferon Production Leukotriene Receptor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Protein Oligomerization Leukotriene Signaling Pathway	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleic Acid Metabolic Process RNA Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Splicing Regulation Of Cell Motility Regulation Of Locomotion Protein Binding Nuclear Body Organization Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Chromatin DNA Binding Negative Regulation Of Macromolecule Metabolic Process Exon-exon Junction Complex RNA Splicing, Via Transesterification Reactions Positive Regulation Of Type I Interferon Production Sin3-type Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Negative Regulation Of MRNA Metabolic Process Alternative MRNA Splicing, Via Spliceosome
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