DDOST

Description		dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Protein Binding Enzyme Activator Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		7 interacting genes: ISG15 LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1
Entrez ID		1650
HPRD ID		03728
Ensembl ID		ENSG00000244038
Uniprot IDs		P39656
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Septin Cytoskeleton Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Leukotriene B4 Receptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Type I Interferon Production Leukotriene Receptor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Protein Oligomerization Leukotriene Signaling Pathway
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