DDOST

Gene Name		dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Translation Protein Glycosylation Protein N-linked Glycosylation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Cytokine T Cell Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Translation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 SRP-dependent cotranslational protein targeting to membrane Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: MAPK6 NXT1 SRSF11 TMEM173
Entrez ID		1650
HPRD ID		03728
Ensembl ID		ENSG00000244038
Uniprot IDs		E7EWT1 P39656
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Export From Nucleus Nuclear Export RNA Transport RNA Localization Interferon-beta Production Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Cytoplasmic Transport Regulation Of Defense Response To Virus By Host Cellular Response To DsRNA Protein Export From Nucleus Positive Regulation Of Transcription Factor Import Into Nucleus Termination Of RNA Polymerase II Transcription
Tagcloud ?		3xflag atp5c1 compatible created creating deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously