DCN and COL4A1

Number of citations of the paper that reports this interaction (PMID 10382266)
26

Data Source:
HPRD (in vivo)

		DCN	COL4A1
Gene Name		decorin	collagen, type IV, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding
	Biological Process	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)	Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)
Protein-Protein Interactions		30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1	27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		1634	1282
HPRD ID		00501	00359
Ensembl ID		ENSG00000011465	ENSG00000187498
Uniprot IDs		P07585 Q6FH10	P02462
PDB IDs			1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Difference) ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Intersection) ?