DCN and MMP7

Number of citations of the paper that reports this interaction (PMID 9148753)
57

Data Source:
HPRD (in vitro)

		DCN	MMP7
Gene Name		decorin	matrix metallopeptidase 7 (matrilysin, uterine)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Cell Proliferation Response To Drug Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)	Prostate cancer ( 23535732)
Protein-Protein Interactions		30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1	16 interactors: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		1634	4316
HPRD ID		00501	01525
Ensembl ID		ENSG00000011465	ENSG00000137673
Uniprot IDs		P07585 Q6FH10	P09237
PDB IDs			1MMP 1MMQ 1MMR 2DDY 2Y6C 2Y6D
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Cell Motility Wound Healing Response To Wounding Immune System Process Locomotion System Development Response To Stress Movement Of Cell Or Subcellular Component Multicellular Organismal Development Organ Development Regulation Of Endopeptidase Activity Positive Regulation Of Keratinocyte Migration Anatomical Structure Development Regulation Of Peptidase Activity Blood Coagulation Hemostasis Glycosaminoglycan Catabolic Process Response To External Stimulus Response To Organic Substance Pathogenesis Response To Lipid Response To Bacterium Developmental Process Dermatan Sulfate Biosynthetic Process Regulation Of Body Fluid Levels Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Bone Resorption Regulation Of Proteolysis Response To Molecule Of Bacterial Origin Tissue Development Response To Other Organism Response To Biotic Stimulus Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Axonogenesis Defense Response Inflammatory Response Response To Stimulus Positive Regulation Of Tissue Remodeling Glycosaminoglycan Metabolic Process Response To Steroid Hormone
Tagcloud ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Difference) ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Intersection) ?