DCN and COL5A1

Number of citations of the paper that reports this interaction (PubMedID 8440685)
0

Data Source:
HPRD (in vitro)

		DCN	COL5A1
Description		decorin	collagen type V alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 29760442 32528159) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)	Blood pressure ( 24954895) Central corneal thickness ( 20719862 22814818 23493294 32528159 28171582 31798171 29760442 30894546) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Femur bone mineral density x serum urate levels interaction ( 34046847) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Longevity ( 20834067) Metabolite levels ( 23823483) Phosphatidylcholine levels ( 31551469) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ADARB1 AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SF1 SFTPD TGFB1 TGFB2 THBS1 TNF	10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1
Entrez ID		1634	1289
HPRD ID		00501	00368
Ensembl ID		ENSG00000011465	ENSG00000130635
Uniprot IDs		P07585 Q6FH10	B2ZZ86 P20908 Q59EE7
PDB IDs			7Y37
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Cellular Response To Amino Acid Stimulus Basement Membrane Collagen Type IV Trimer Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Extracellular Space Collagen Fibril Organization Collagen Metabolic Process Collagen-activated Signaling Pathway Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cell Motility Animal Organ Morphogenesis Regulation Of Locomotion Regulation Of Smooth Muscle Cell Proliferation Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Alpha Granule Lumen Extracellular Matrix Assembly Integrin Binding Face Morphogenesis Tissue Development Negative Regulation Of Cell Population Proliferation Fibrillar Collagen Trimer Positive Regulation Of Smooth Muscle Cell Proliferation Salivary Gland Morphogenesis Response To Xenobiotic Stimulus Cell Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Response To Mechanical Stimulus Protease Binding	Extracellular Matrix Collagen Binding Platelet Alpha Granule Lumen Golgi Lumen Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Extracellular Matrix Binding Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Region Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Platelet-derived Growth Factor Binding Cell Surface Regulation Of Glomerular Mesangial Cell Proliferation Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Autophosphorylation Proteoglycan Binding Platelet-derived Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Positive Regulation Of Endothelial Cell Migration Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Platelet Alpha Granule Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Anatomical Structure Morphogenesis Regulation Of Endothelial Cell Proliferation Growth Factor Activity Regulation Of Developmental Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Regulation Of Response To Wounding Regulation Of Cell Motility Regulation Of Locomotion Response To Wounding Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phospholipid Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion
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