Wiki-Pi
About
Search
People
Updates
Search
DCN and COL4A6
Number of citations of the paper that reports this interaction (PubMedID
10382266
)
0
Data Source:
HPRD
(in vivo)
DCN
COL4A6
Description
decorin
collagen type IV alpha 6 chain
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Lumen
Extracellular Matrix
Lysosomal Lumen
Extracellular Region
Collagen Trimer
Collagen Type IV Trimer
Basement Membrane
Endoplasmic Reticulum Lumen
Extracellular Matrix
Molecular Function
RNA Binding
Protein Binding
Glycosaminoglycan Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Extracellular Matrix Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Biological Process
Animal Organ Morphogenesis
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Macroautophagy
Negative Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Cell Adhesion
Extracellular Matrix Organization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Cellular Response To Amino Acid Stimulus
Pathways
Degradation of the extracellular matrix
Glycosaminoglycan-protein linkage region biosynthesis
CS-GAG biosynthesis
DS-GAG biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Collagen chain trimerization
Attachment of bacteria to epithelial cells
Drugs
Diseases
Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS
Blood protein levels (
30072576
)
Central corneal thickness (
29760442
32528159
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Sudden cardiac arrest (
21658281
)
Electrodermal activity (
25387706
)
Interacting Genes
32 interacting genes:
ADARB1
AHSG
BRCA1
C1QA
CCN4
COL14A1
COL1A1
COL1A2
COL4A1
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
DPT
EGFR
ELN
FBN1
FLNA
FN1
MET
MMP2
MMP3
MMP7
PLA2G2A
SF1
SFTPD
TGFB1
TGFB2
THBS1
TNF
12 interacting genes:
APP
CD93
DCN
FBLN2
FN1
HABP2
MAGEA6
MATN2
MMP9
NOTCH1
OSM
SERPINE2
Entrez ID
1634
1288
HPRD ID
00501
02364
Ensembl ID
ENSG00000011465
ENSG00000197565
Uniprot IDs
P07585
Q6FH10
A0A087WZY5
A8MXH5
A8VPY0
B2RTX6
B7ZMM7
F5H3Q5
Q14031
PDB IDs
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent
Collagen Trimer
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Endoplasmic Reticulum Lumen
Cellular Response To Amino Acid Stimulus
Basement Membrane
Collagen Type IV Trimer
Response To Amino Acid
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Platelet-derived Growth Factor Binding
Extracellular Space
Collagen Fibril Organization
Collagen Metabolic Process
Collagen-activated Signaling Pathway
Cell Adhesion
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Cell Motility
Animal Organ Morphogenesis
Regulation Of Locomotion
Regulation Of Smooth Muscle Cell Proliferation
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Animal Organ Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Platelet Alpha Granule Lumen
Extracellular Matrix Assembly
Integrin Binding
Face Morphogenesis
Tissue Development
Negative Regulation Of Cell Population Proliferation
Fibrillar Collagen Trimer
Positive Regulation Of Smooth Muscle Cell Proliferation
Salivary Gland Morphogenesis
Response To Xenobiotic Stimulus
Cell Morphogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Adhesion
Response To Mechanical Stimulus
Protease Binding
Extracellular Region
Extracellular Matrix
Glycosaminoglycan Binding
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peptidase Activator Activity
Extracellular Space
Regulation Of Cell Migration
Regulation Of Locomotion
Regulation Of Cell Motility
Calcium Ion Binding
Regulation Of Development, Heterochronic
Positive Regulation Of Astrocyte Differentiation
Regulation Of Timing Of Cell Differentiation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Extracellular Matrix Structural Constituent
Platelet Alpha Granule
Signaling Receptor Binding
Regulation Of Intracellular Signal Transduction
Heparin Binding
Negative Regulation Of Transport
Extracellular Matrix Binding
Regulation Of Astrocyte Differentiation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Endodermal Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Glial Cell Differentiation
Amyloid-beta Complex
Regulation Of Phosphorus Metabolic Process
Growth Cone Lamellipodium
Regulation Of Growth
Regulation Of Developmental Process
Regulation Of Response To Calcium Ion
Regulation Of Cell Population Proliferation
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Extracellular Matrix Organization
Positive Regulation Of Signal Transduction
Dendrite Development
Extracellular Structure Organization
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Neurogenesis
Response To Wounding
Negative Regulation Of Epithelial Cell Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?