DCN and COL6A1

Number of citations of the paper that reports this interaction (PMID 1544908)
42

Data Source:
BioGRID (pull down)

		DCN	COL6A1
Gene Name		decorin	collagen, type VI, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Sarcolemma Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding	Platelet-derived Growth Factor Binding
	Biological Process	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process	Osteoblast Differentiation Cell Adhesion Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Protein Heterotrimerization Cellular Response To Amino Acid Stimulus
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1	9 interactors: COL2A1 DCN DNAJB11 FGF7 LAMB1 LGALS3BP MAG PDGFA PDGFB
Entrez ID		1634	1291
HPRD ID		00501	00370
Ensembl ID		ENSG00000011465	ENSG00000142156
Uniprot IDs		P07585 Q6FH10	P12109
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Organ Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Chemotaxis Locomotion Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Wounding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Organic Substance Extracellular Matrix Disassembly Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Positive Regulation Of Cell Division Response To External Stimulus Organ Development Regulation Of Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Negative Regulation Of Platelet Activation Positive Regulation Of Epithelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Migration Wound Healing Positive Chemotaxis Branching Involved In Salivary Gland Morphogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Platelet Activation Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Locomotion
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Tagcloud (Difference) ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	6365g aetiologies bethlem bioinformaticians commercialisation consumer definitively eventual expertise faced flagged geneticists gly2122val hitherto journey myopathy neuromuscular pointed pursued realising reassessment sanger sidetracked son table uncharacterised unprecedented
Tagcloud (Intersection) ?