DCN and COL1A2

Number of citations of the paper that reports this interaction (PubMedID 2375748)
34

Data Source:
HPRD (in vitro, in vivo)

		DCN	COL1A2
Description		decorin	collagen type I alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Animal Organ Development Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy	Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 29760442 32528159) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)	Aging ( 22773346) Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		32 interacting genes: ADARB1 AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SF1 SFTPD TGFB1 TGFB2 THBS1 TNF	31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF
Entrez ID		1634	1278
HPRD ID		00501	00363
Ensembl ID		ENSG00000011465	ENSG00000164692
Uniprot IDs		P07585 Q6FH10	A0A0S2Z3H5 P08123
PDB IDs			5CTD 5CTI 5CVA 6JEC
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Cellular Response To Amino Acid Stimulus Basement Membrane Collagen Type IV Trimer Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Extracellular Space Collagen Fibril Organization Collagen Metabolic Process Collagen-activated Signaling Pathway Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cell Motility Animal Organ Morphogenesis Regulation Of Locomotion Regulation Of Smooth Muscle Cell Proliferation Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Alpha Granule Lumen Extracellular Matrix Assembly Integrin Binding Face Morphogenesis Tissue Development Negative Regulation Of Cell Population Proliferation Fibrillar Collagen Trimer Positive Regulation Of Smooth Muscle Cell Proliferation Salivary Gland Morphogenesis Response To Xenobiotic Stimulus Cell Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Response To Mechanical Stimulus Protease Binding	Collagen Binding Extracellular Matrix Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Extracellular Matrix Extracellular Matrix Structural Constituent Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Integrin Binding Cell Surface Cell-substrate Adhesion Extracellular Region Platelet Alpha Granule Membrane Golgi Lumen Cell-matrix Adhesion Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Migration Extracellular Space Identical Protein Binding Regulation Of Cell Motility Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Adhesion Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process TRC Complex Positive Regulation Of ERAD Pathway Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Smooth Muscle Cell Migration Integrin AlphaIIb-beta3 Complex Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Body Fluid Levels
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