DCN and WISP1

Number of citations of the paper that reports this interaction (PMID 11598131)
23

Data Source:
HPRD (in vitro)

		DCN	WISP1
Gene Name		decorin	WNT1 inducible signaling pathway protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm
	Molecular Function	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Wnt Signaling Pathway Negative Regulation Of Cell Death
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Sudden cardiac arrest ( 21658281)	Graves' disease ( 23612905) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1	2 interactors: BGN DCN
Entrez ID		1634	8840
HPRD ID		00501	16019
Ensembl ID		ENSG00000011465
Uniprot IDs		P07585 Q6FH10	O95388
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration	Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Peptide Cross-linking Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Glycosaminoglycan Metabolic Process Pathogenesis Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Monocarboxylic Acid Metabolic Process Peptidyl-amino Acid Modification Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Organic Acid Metabolic Process Blood Vessel Remodeling Catabolic Process Extracellular Matrix Disassembly Tissue Remodeling Small Molecule Metabolic Process Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Placenta Development Response To Mechanical Stimulus Cellular Protein Modification Process Muscle Organ Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Kidney Development Striated Muscle Tissue Development Response To Lipopolysaccharide Aging Renal System Development Response To Molecule Of Bacterial Origin Muscle Tissue Development Urogenital System Development Cellular Protein Metabolic Process
Tagcloud ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	began calories cancerous carcinogen catenin chow continued corresponded den diethylnitrosamine ethanol etoh foci gsk3beta hepatocyte initiating insult livers mmp7 multiplicity pair pf promotion retinol stores tumorigenic wnt2 wnt7a wnts
Tagcloud (Difference) ?		architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion	began calories cancerous carcinogen catenin chow continued corresponded den diethylnitrosamine ethanol etoh foci gsk3beta hepatocyte initiating insult livers mmp7 multiplicity pair pf promotion retinol stores tumorigenic wnt2 wnt7a wnts
Tagcloud (Intersection) ?