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CYP2C8 and A2M
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
CYP2C8
A2M
Description
cytochrome P450 family 2 subfamily C member 8
alpha-2-macroglobulin
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Intracellular Membrane-bounded Organelle
Extracellular Region
Extracellular Space
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Molecular Function
Monooxygenase Activity
Iron Ion Binding
Protein Binding
Arachidonate Epoxygenase Activity
Retinoic Acid 4-hydroxylase Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Heme Binding
Caffeine Oxidase Activity
Metal Ion Binding
Estrogen 16-alpha-hydroxylase Activity
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Peptidase Inhibitor Activity
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Biological Process
Lipid Hydroxylation
Organic Acid Metabolic Process
Lipid Metabolic Process
Terpenoid Metabolic Process
Xenobiotic Metabolic Process
Steroid Metabolic Process
Estrogen Metabolic Process
Arachidonate Metabolic Process
Epoxygenase P450 Pathway
Monocarboxylic Acid Metabolic Process
Xenobiotic Catabolic Process
Retinol Metabolic Process
Retinoic Acid Metabolic Process
Long-chain Fatty Acid Biosynthetic Process
Icosanoid Biosynthetic Process
Oxidative Demethylation
Omega-hydroxylase P450 Pathway
Negative Regulation Of Complement Activation, Lectin Pathway
Stem Cell Differentiation
Pathways
Xenobiotics
CYP2E1 reactions
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Biosynthesis of maresin-like SPMs
Aspirin ADME
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
HDL assembly
Drugs
Isoniazid
Palmitic Acid
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Gout (
22179738
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Low density lipoprotein cholesterol levels (
33339817
)
Osteonecrosis of the jaw (
18594024
)
Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia (
30922102
)
Response to clopidogrel therapy (
19706858
)
Serum metabolite levels (
33031748
)
Total cholesterol levels (
33339817
)
Triglyceride levels in HIV infection (
33109212
)
Tuberculosis (
24057671
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Warfarin maintenance dose (
23755828
)
Refractive error (
32231278
)
Interacting Genes
12 interacting genes:
A2M
APOE
BLMH
DNAJB1
ECSIT
EXOC6
IFIT3
LONP1
MAST1
PSEN1
RIN3
RNF32
99 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSP90AA1
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SLC6A4
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
USP40
Entrez ID
1558
2
HPRD ID
03083
00072
Ensembl ID
ENSG00000138115
ENSG00000175899
Uniprot IDs
B7Z1F5
P10632
P01023
PDB IDs
1PQ2
2NNH
2NNI
2NNJ
2VN0
1BV8
2P9R
6TAV
7O7L
7O7M
7O7N
7O7O
7O7P
7O7Q
7O7R
7O7S
7VON
7VOO
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Amyloid Fibril Formation
Neuronal Cell Body
Regulation Of Amyloid Fibril Formation
Regulation Of Inclusion Body Assembly
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Phospholipid Efflux
Negative Regulation Of Postsynaptic Membrane Organization
Positive Regulation Of Lipid Transport Across Blood-brain Barrier
Dendrite
Negative Regulation Of Lipid Transport Across Blood-brain Barrier
Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus
Positive Regulation Of Dendritic Spine Development
Cellular Response To Amyloid-beta
Regulation Of Dendritic Spine Development
Metal Chelating Activity
Intermediate-density Lipoprotein Particle Clearance
Aggresome
Negative Regulation Of Core Promoter Binding
Oxidation-dependent Protein Catabolic Process
Negative Regulation Of Mast Cell Chemotaxis
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Presynaptic Membrane Organization
Endosome
Response To Amyloid-beta
Chylomicron Remnant
Maintenance Of Location In Cell
Early Endosome
Lipid Transport Involved In Lipid Storage
Lipoprotein Particle
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Neurofibrillary Tangle Assembly
Discoidal High-density Lipoprotein Particle
Cysteine-type Aminopeptidase Activity
Forebrain Development
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Cajal-Retzius Cell Differentiation
Maintenance Of Location
ATPase Binding
Interleukin-8 Binding
Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Response To Oxidative Stress
Positive Regulation Of Protein Folding
Protein Catabolic Process At Postsynapse
Negative Regulation Of Transcription Regulatory Region DNA Binding
Response To Aluminum Ion
Mitochondrial Promoter Sequence-specific DNA Binding
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Blood Microparticle
Negative Regulation Of Multicellular Organismal Process
Extracellular Exosome
Extracellular Space
Peptidase Activity
Ovulation From Ovarian Follicle
Regulation Of Cell Activation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Hydrolase Activity
Ovulation
Regulation Of Multicellular Organismal Process
Response To Stress
Regulation Of Blood Coagulation
Negative Regulation Of Platelet Activation
Regulation Of Hemostasis
Extracellular Region
Regulation Of Amyloid-beta Clearance
Positive Regulation Of Cell Adhesion
Smooth Muscle Adaptation
Regulation Of Programmed Cell Death
Regulation Of Immune Response
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Proteolysis
Negative Regulation Of Coagulation
Regulation Of Cell Adhesion
Regulation Of Biological Quality
Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Apoptotic Process
Positive Regulation Of Cell Activation
Identical Protein Binding
Positive Regulation Of Protein Metabolic Process
Protein Refolding
Positive Regulation Of Cell Migration
Positive Regulation Of Multicellular Organismal Process
Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Lymphocyte Activation
Regulation Of Transport
Melanosome
Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Smooth Muscle Cell Proliferation
Serine-type Endopeptidase Activity
Positive Regulation Of Cell Motility
Extracellular Matrix
Lipoprotein Particle
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Regulation Of Nitric Oxide Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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