CYP2C8 and IFIT3

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C8	IFIT3
Description		cytochrome P450 family 2 subfamily C member 8	interferon induced protein with tetratricopeptide repeats 3
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity	Protein Binding Identical Protein Binding
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Immune System Process Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Interferon alpha/beta signaling
Drugs		Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Low density lipoprotein cholesterol levels ( 33339817) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Serum metabolite levels ( 33031748) Total cholesterol levels ( 33339817) Triglyceride levels in HIV infection ( 33109212) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)	Hormone measurements ( 30576415)
Interacting Genes		12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32	21 interacting genes: A2M ANXA1 APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3
Entrez ID		1558	3437
HPRD ID		03083	05228
Ensembl ID		ENSG00000138115	ENSG00000119917
Uniprot IDs		B7Z1F5 P10632	A0A7P0T7D6 O14879 Q5T765
PDB IDs		1PQ2 2NNH 2NNI 2NNJ 2VN0	6C6K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Neuronal Cell Body Regulation Of Amyloid Fibril Formation Regulation Of Inclusion Body Assembly Amyloid Precursor Protein Metabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Dendrite Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Aggresome Negative Regulation Of Core Promoter Binding Oxidation-dependent Protein Catabolic Process Negative Regulation Of Mast Cell Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Endosome Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Early Endosome Lipid Transport Involved In Lipid Storage Lipoprotein Particle Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Cysteine-type Aminopeptidase Activity Forebrain Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Maintenance Of Location ATPase Binding Interleukin-8 Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Oxidative Stress Positive Regulation Of Protein Folding Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Response To Aluminum Ion Mitochondrial Promoter Sequence-specific DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune System Process Blood Microparticle	Negative Regulation Of Viral Translation RNA Sequestering Activity Muscle Thin Filament Tropomyosin Regulation Of Viral Process Response To Stress Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Actin Filament Amyloid Precursor Protein Metabolic Process Defense Response To Virus Regulation Of Viral Life Cycle Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Response To Virus Positive Regulation Of Viral Genome Replication Positive Regulation Of Heart Rate By Epinephrine Oxidation-dependent Protein Catabolic Process
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