CYP2C8 and DNAJB1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C8	DNAJB1
Description		cytochrome P450 family 2 subfamily C member 8	DnaJ heat shock protein family (Hsp40) member B1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Transcription Regulator Inhibitor Activity
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Forebrain Development Cellular Response To Heat Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Protein Folding
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs		Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Low density lipoprotein cholesterol levels ( 33339817) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Serum metabolite levels ( 33031748) Total cholesterol levels ( 33339817) Triglyceride levels in HIV infection ( 33109212) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32	33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CEBPA CENPE CYP2C8 DNAJC3 DYRK3 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PPDPF PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36
Entrez ID		1558	3337
HPRD ID		03083	05198
Ensembl ID		ENSG00000138115	ENSG00000132002
Uniprot IDs		B7Z1F5 P10632	P25685 Q6FHS4
PDB IDs		1PQ2 2NNH 2NNI 2NNJ 2VN0	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N 7NDX 8FE2 8FE5 8FEC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Neuronal Cell Body Regulation Of Amyloid Fibril Formation Regulation Of Inclusion Body Assembly Amyloid Precursor Protein Metabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Dendrite Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Aggresome Negative Regulation Of Core Promoter Binding Oxidation-dependent Protein Catabolic Process Negative Regulation Of Mast Cell Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Endosome Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Early Endosome Lipid Transport Involved In Lipid Storage Lipoprotein Particle Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Cysteine-type Aminopeptidase Activity Forebrain Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Maintenance Of Location ATPase Binding Interleukin-8 Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Oxidative Stress Positive Regulation Of Protein Folding Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Response To Aluminum Ion Mitochondrial Promoter Sequence-specific DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune System Process Blood Microparticle	Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Intracellular Signal Transduction Response To Temperature Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Heat Cellular Response To Metal Ion Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Regulation Of Developmental Growth Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Intracellular Signaling Cassette Misfolded Protein Binding Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Apoptotic Process Heat Shock Protein Binding Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Response To Peptide Regulation Of Cell Growth Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Cellular Response To Topologically Incorrect Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Regulation Of Cell Development Signal Transduction Regulation Of Cell Cycle Response To Stress Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Apoptotic Process
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