CYP2C8 and BLMH

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C8	BLMH
Description		cytochrome P450 family 2 subfamily C member 8	bleomycin hydrolase
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Cysteine-type Aminopeptidase Activity
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Protein Polyubiquitination Proteolysis Response To Xenobiotic Stimulus Response To Toxic Substance Homocysteine Catabolic Process
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Low density lipoprotein cholesterol levels ( 33339817) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Serum metabolite levels ( 33031748) Total cholesterol levels ( 33339817) Triglyceride levels in HIV infection ( 33109212) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32	20 interacting genes: AP1M2 APP CDC42 CEBPA CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I
Entrez ID		1558	642
HPRD ID		03083	03870
Ensembl ID		ENSG00000138115	ENSG00000108578
Uniprot IDs		B7Z1F5 P10632	Q13867
PDB IDs		1PQ2 2NNH 2NNI 2NNJ 2VN0	1CB5 2CB5 7V5L 7V5S 7V5T 7XF9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Neuronal Cell Body Regulation Of Amyloid Fibril Formation Regulation Of Inclusion Body Assembly Amyloid Precursor Protein Metabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Dendrite Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Aggresome Negative Regulation Of Core Promoter Binding Oxidation-dependent Protein Catabolic Process Negative Regulation Of Mast Cell Chemotaxis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Endosome Response To Amyloid-beta Chylomicron Remnant Maintenance Of Location In Cell Early Endosome Lipid Transport Involved In Lipid Storage Lipoprotein Particle Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Cysteine-type Aminopeptidase Activity Forebrain Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Maintenance Of Location ATPase Binding Interleukin-8 Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Oxidative Stress Positive Regulation Of Protein Folding Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Response To Aluminum Ion Mitochondrial Promoter Sequence-specific DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune System Process Blood Microparticle	Cytosol Cytoplasm Postsynapse Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity
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