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CYP2C8
Description
cytochrome P450 family 2 subfamily C member 8
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Monooxygenase Activity
Iron Ion Binding
Protein Binding
Arachidonate Epoxygenase Activity
Retinoic Acid 4-hydroxylase Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Heme Binding
Caffeine Oxidase Activity
Metal Ion Binding
Estrogen 16-alpha-hydroxylase Activity
Biological Process
Lipid Hydroxylation
Organic Acid Metabolic Process
Lipid Metabolic Process
Terpenoid Metabolic Process
Xenobiotic Metabolic Process
Steroid Metabolic Process
Estrogen Metabolic Process
Arachidonate Metabolic Process
Epoxygenase P450 Pathway
Monocarboxylic Acid Metabolic Process
Xenobiotic Catabolic Process
Retinol Metabolic Process
Retinoic Acid Metabolic Process
Long-chain Fatty Acid Biosynthetic Process
Icosanoid Biosynthetic Process
Oxidative Demethylation
Omega-hydroxylase P450 Pathway
Pathways
Xenobiotics
CYP2E1 reactions
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Biosynthesis of maresin-like SPMs
Aspirin ADME
Drugs
Isoniazid
Palmitic Acid
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS
Gout (
22179738
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Low density lipoprotein cholesterol levels (
33339817
)
Osteonecrosis of the jaw (
18594024
)
Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia (
30922102
)
Response to clopidogrel therapy (
19706858
)
Serum metabolite levels (
33031748
)
Total cholesterol levels (
33339817
)
Triglyceride levels in HIV infection (
33109212
)
Tuberculosis (
24057671
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Warfarin maintenance dose (
23755828
)
Interacting Genes
12 interacting genes:
A2M
APOE
BLMH
DNAJB1
ECSIT
EXOC6
IFIT3
LONP1
MAST1
PSEN1
RIN3
RNF32
Entrez ID
1558
HPRD ID
03083
Ensembl ID
ENSG00000138115
Uniprot IDs
B7Z1F5
P10632
PDB IDs
1PQ2
2NNH
2NNI
2NNJ
2VN0
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Amyloid Fibril Formation
Neuronal Cell Body
Regulation Of Amyloid Fibril Formation
Regulation Of Inclusion Body Assembly
Amyloid Precursor Protein Metabolic Process
Negative Regulation Of Phospholipid Efflux
Negative Regulation Of Postsynaptic Membrane Organization
Positive Regulation Of Lipid Transport Across Blood-brain Barrier
Dendrite
Negative Regulation Of Lipid Transport Across Blood-brain Barrier
Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus
Positive Regulation Of Dendritic Spine Development
Cellular Response To Amyloid-beta
Regulation Of Dendritic Spine Development
Metal Chelating Activity
Intermediate-density Lipoprotein Particle Clearance
Aggresome
Negative Regulation Of Core Promoter Binding
Oxidation-dependent Protein Catabolic Process
Negative Regulation Of Mast Cell Chemotaxis
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Presynaptic Membrane Organization
Endosome
Response To Amyloid-beta
Chylomicron Remnant
Maintenance Of Location In Cell
Early Endosome
Lipid Transport Involved In Lipid Storage
Lipoprotein Particle
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Neurofibrillary Tangle Assembly
Discoidal High-density Lipoprotein Particle
Cysteine-type Aminopeptidase Activity
Forebrain Development
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Cajal-Retzius Cell Differentiation
Maintenance Of Location
ATPase Binding
Interleukin-8 Binding
Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Response To Oxidative Stress
Positive Regulation Of Protein Folding
Protein Catabolic Process At Postsynapse
Negative Regulation Of Transcription Regulatory Region DNA Binding
Response To Aluminum Ion
Mitochondrial Promoter Sequence-specific DNA Binding
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Blood Microparticle
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