RNF150 and UBE2Z

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF150	UBE2Z
Description		ring finger protein 150	ubiquitin conjugating enzyme E2 Z
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Molecular Adaptor Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hip index ( 34021172) Malaria ( 31844061) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 29358691 30054458)
Interacting Genes		12 interacting genes: C3orf52 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2L3 UBE2L6 UBE2U UBE2W UBE2Z	40 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 HUWE1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		57484	65264
HPRD ID		15258	08589
Ensembl ID		ENSG00000170153	ENSG00000159202
Uniprot IDs		D6RIE5 Q9ULK6	Q9H832
PDB IDs			5A4P
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity Proteolysis ATP Binding Nucleotide Binding Catabolic Process Protein Metabolic Process Protein Monoubiquitination Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity ISG15-protein Conjugation Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Nucleoplasm Positive Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Targeting To Mitochondrion Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Nucleus TOR Signaling Ubiquitin Protein Ligase Activity Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus HULC Complex Positive Regulation Of Post-translational Protein Modification Regulation Of TOR Signaling DNA Repair	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Metal Ion Binding Macromolecule Catabolic Process Protein Metabolic Process Zinc Ion Binding Transferase Activity Proteolysis Endoplasmic Reticulum Mannose Trimming Response To Stress Macromolecule Metabolic Process Protein Alpha-1,2-demannosylation Catabolic Process Proteasomal Protein Catabolic Process Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Protein K63-linked Ubiquitination Protein Catabolic Process ERAD Pathway Protein K48-linked Ubiquitination I-SMAD Binding Cellular Response To Stress Protein Destabilization Ubiquitin Activating Enzyme Activity Response To Endoplasmic Reticulum Stress Regulation Of Protein Stability Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Protein Ligase Binding Aggresome Assembly Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Complex Negative Regulation Of Mitochondrial Fusion Heteromeric SMAD Protein Complex Derlin-1 Retrotranslocation Complex Protein-containing Complex Binding Negative Regulation Of Type I Interferon Production Regulation Of Mitophagy Cytoplasm
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