NKX2-5 and FOXH1

Number of citations of the paper that reports this interaction (PubMedID 15363409)
0

Data Source:
HPRD (in vitro)

		NKX2-5	FOXH1
Description		NK2 homeobox 5	forkhead box H1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis	Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm
Drugs
Diseases		Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060 30046033 32439900) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10	68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503
Entrez ID		1482	8928
HPRD ID		02787	04689
Ensembl ID		ENSG00000183072	ENSG00000160973
Uniprot IDs		A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952	O75593
PDB IDs		3RKQ 4S0H 6WC2 6WC5	5XOC 7YZB
Enriched GO Terms of Interacting Partners?		Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation	Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis
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