FOXH1 and RECQL4

		FOXH1	RECQL4
Description		forkhead box H1	RecQ like helicase 4
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Bubble DNA Binding Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Oxidized Purine DNA Binding 3'-5' DNA Helicase Activity Metal Ion Binding Telomeric D-loop Binding Catalytic Activity, Acting On DNA DNA/DNA Annealing Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Chromosome Organization Telomeric D-loop Disassembly
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm
Drugs
Diseases			RAPADILINO syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	11 interacting genes: ACD EP300 MARCHF5 MCM10 POT1 PRSS23 RNF8 TERF1 TERF2IP TOMM20 WRAP53
Entrez ID		8928	9401
HPRD ID		04689	04805
Ensembl ID		ENSG00000160973	ENSG00000160957
Uniprot IDs		O75593	A0A087X072 O94761
PDB IDs		5XOC 7YZB	2KMU 5LST
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	Telomere Maintenance Via Telomerase Shelterin Complex RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomere Capping Positive Regulation Of Telomere Maintenance Chromosome, Telomeric Region Telomere Assembly DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Telomere Organization Regulation Of Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Organelle Chromosome DNA Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Organization Regulation Of Double-strand Break Repair Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization DNA Damage Response Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Repair Telomeric D-loop Disassembly Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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