FOXH1 and UBAP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FOXH1	UBAP2
Name		forkhead box H1	ubiquitin associated protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	P-body Nucleus Chromosome Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	RNA Binding Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Regulation Of Gene Expression Hematopoietic Stem Cell Homeostasis
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm	None
GWAS		Blood metabolite levels ( 26401656 ) Educational attainment ( 25201988 ) General cognitive ability ( 29844566 )	Adult body size ( 32376654 ) Bipolar disorder ( 20351715 ) Daytime nap ( 33568662 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Mosquito bite size ( 28199695 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Type 2 diabetes ( 30297969 30054458 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )
Novel Interactors		4 novel interactors: LRRC14 RECQL4 RPL8 SUPT20H	2 novel interactors: GBA2 TMEM8B
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	45 interacting genes: ASB13 ATPAF2 BANP C10orf55 CREM DAZAP2 EFHC1 FAM168B FNDC3B FOXH1 HGS IGFN1 ISX ITCH JMJD7 KANK2 KRTAP15-1 LCK MGAT5B NOXA1 NPAS2 NUTF2 OTX1 PLAC8 PLEKHB2 PPP2CA PRSS53 PSMB8 RBPMS RHOXF2 SHC3 SPAG8 SPMIP9 TENT5B TEP1 TFG TLE5 TP53BP1 TRAPPC6A UBC USP7 VENTX VPS37C WRAP53 ZNF34
Entrez ID		8928	55833
HPRD ID		04689	06748
Ensembl ID		ENSG00000160973	ENSG00000137073
Uniprot IDs		O75593	A0A8C8MQ70 B4DH66 B7Z7P2 Q5T6F2 Q9P0H6
PDB IDs		5XOC 7YZB	Not available
GO Terms Enriched among Interactors		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	P53 Binding Axonemal A Tubule Inner Sheath Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome