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NKX2-5 and GATA4
Number of citations of the paper that reports this interaction (PMID
9312027
)
105
Data Source:
HPRD
(in vitro, in vivo)
NKX2-5
GATA4
Gene Name
NK2 homeobox 5
GATA binding protein 4
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Transcription Factor Complex
Cytoplasm
RNA Polymerase II Transcription Factor Complex
Nuclear Chromatin
Nucleus
Nucleoplasm
RNA Polymerase II Transcription Factor Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Cofactor Activity
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
Enhancer Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Activating Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
NFAT Protein Binding
Co-SMAD Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Vasculogenesis
Heart Looping
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Bundle Of His Development
Purkinje Myocyte Differentiation
Cardiac Ventricle Formation
Right Ventricular Cardiac Muscle Tissue Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Septum Secundum Development
Proepicardium Development
Pulmonary Myocardium Development
Transcription From RNA Polymerase II Promoter
Adult Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Sodium Ion Transport
Negative Regulation Of Myotube Differentiation
Hemopoiesis
Cell Differentiation
BMP Signaling Pathway
Thyroid Gland Development
Embryonic Heart Tube Development
Negative Regulation Of Apoptotic Process
Sarcomere Organization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Heart Contraction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Spleen Development
Positive Regulation Of Cardioblast Differentiation
Ventricular Cardiac Myofibril Assembly
Cardiac Muscle Cell Differentiation
Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Regulation Of Cardiac Muscle Contraction
Pharyngeal System Development
Cardiac Muscle Cell Proliferation
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Contraction
Canonical Wnt Signaling Pathway
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Heart Trabecula Formation
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Atrioventricular Node Cell Development
Atrioventricular Node Cell Fate Commitment
Embryonic Heart Tube Left/right Pattern Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Voltage-gated Calcium Channel Activity
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Endoderm Formation
Heart Looping
Atrioventricular Valve Formation
Endocardial Cushion Development
Cardiac Ventricle Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Cardiac Muscle Tissue Development
Ventricular Septum Development
Atrial Septum Primum Morphogenesis
Atrial Septum Secundum Morphogenesis
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cell-cell Signaling
Spermatogenesis
Endoderm Development
Blood Coagulation
Male Gonad Development
Response To Mechanical Stimulus
Negative Regulation Of Autophagy
Positive Regulation Vascular Endothelial Growth Factor Production
Cardiac Muscle Hypertrophy In Response To Stress
Signal Transduction Involved In Regulation Of Gene Expression
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Response To Retinoic Acid
Embryonic Heart Tube Anterior/posterior Pattern Specification
Atrioventricular Canal Development
Response To Drug
Response To Estrogen
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Digestive Tract Morphogenesis
Embryonic Foregut Morphogenesis
Positive Regulation Of Cardioblast Differentiation
Sertoli Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Transdifferentiation
SMAD Protein Signal Transduction
Atrial Septum Morphogenesis
Lung Lobe Formation
Intestinal Epithelial Cell Differentiation
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Glucose Stimulus
Cellular Response To Follicle-stimulating Hormone Stimulus
Epithelial Cell Fate Commitment
Seminiferous Tubule Development
Regulation Of Cardiac Muscle Cell Contraction
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Peptide hormone metabolism
Generic Transcription Pathway
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Factors involved in megakaryocyte development and platelet production
Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Heart rate (
23583979
)
Infantile hypertrophic pyloric stenosis (
22306654
)
PR interval (
20062060
)
Myopia (pathological) (
23049088
)
Retinal vascular caliber (
21060863
)
Protein-Protein Interactions
13 interactors:
CAMTA2
CSNK2A1
FOXH1
GATA4
HDAC1
HIPK1
HIPK2
JARID2
KDM6A
SRF
TBX2
TBX5
TLE1
23 interactors:
ALX4
CRIP2
EP300
FOS
HAND2
ID1
ID2
ID3
JARID2
MAPK1
MAPK3
MDC1
MED1
MEF2C
NFATC4
NKX2-5
NR5A1
PIAS1
SP1
SRF
TBX5
ZBTB3
ZFPM2
Entrez ID
1482
2626
HPRD ID
02787
08994
Ensembl ID
ENSG00000183072
ENSG00000136574
Uniprot IDs
P52952
B3KUF4
B7ZKZ4
P43694
PDB IDs
3RKQ
2M9W
Enriched GO Terms of Interacting Partners
?
Organ Morphogenesis
Embryonic Morphogenesis
Transcription, DNA-templated
RNA Biosynthetic Process
Embryonic Organ Morphogenesis
Tissue Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
RNA Metabolic Process
Embryo Development
Anatomical Structure Morphogenesis
Heart Morphogenesis
Gene Expression
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Pattern Specification Process
Anterior/posterior Pattern Specification
Embryonic Organ Development
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Chamber Development
Organ Development
System Development
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Tissue Development
Cardiac Muscle Tissue Development
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Anatomical Structure Development
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Growth
Positive Regulation Of Cell Proliferation
Cellular Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Heart Development
Developmental Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Aorta Morphogenesis
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cardiac Muscle Cell Proliferation
Aorta Development
Striated Muscle Tissue Development
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Tissue Development
RNA Metabolic Process
Heart Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Gene Expression
Organ Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Organ Development
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cardiovascular System Development
Cardiac Chamber Development
Tube Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cardiac Ventricle Development
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Nitrogen Compound Metabolic Process
Embryonic Organ Development
Muscle Structure Development
Biosynthetic Process
Regulation Of Gene Expression
System Development
Regulation Of Nitrogen Compound Metabolic Process
Epithelium Development
Embryo Development
Striated Muscle Tissue Development
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Muscle Tissue Development
Anatomical Structure Morphogenesis
Blood Vessel Development
Anatomical Structure Development
Heart Morphogenesis
Vasculature Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cardiac Ventricle Morphogenesis
Tagcloud
?
6j
arm
assigned
assignment
backcross
c57bl
chromosome
closely
clu
determination
disorganization
dnas
ds
ectopic
f1
hybrid
kb
lineage
mapped
mapping
mus
places
rodent
somatic
southern
speculate
spretus
vicinity
Tagcloud (Difference)
?
6j
arm
assigned
assignment
backcross
c57bl
chromosome
closely
clu
determination
disorganization
dnas
ds
ectopic
f1
hybrid
kb
lineage
mapped
mapping
mus
places
rodent
somatic
southern
speculate
spretus
vicinity
Tagcloud (Intersection)
?