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NKX2-5 and CAMTA2
Number of citations of the paper that reports this interaction (PMID
16678093
)
36
Data Source:
HPRD
(in vitro)
NKX2-5
CAMTA2
Gene Name
NK2 homeobox 5
calmodulin binding transcription activator 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Transcription Factor Complex
Cytoplasm
RNA Polymerase II Transcription Factor Complex
Nucleus
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Cofactor Activity
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
DNA Binding
Chromatin Binding
Protein Binding
Transcription Factor Binding
Histone Deacetylase Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Vasculogenesis
Heart Looping
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Bundle Of His Development
Purkinje Myocyte Differentiation
Cardiac Ventricle Formation
Right Ventricular Cardiac Muscle Tissue Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Septum Secundum Development
Proepicardium Development
Pulmonary Myocardium Development
Transcription From RNA Polymerase II Promoter
Adult Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Sodium Ion Transport
Negative Regulation Of Myotube Differentiation
Hemopoiesis
Cell Differentiation
BMP Signaling Pathway
Thyroid Gland Development
Embryonic Heart Tube Development
Negative Regulation Of Apoptotic Process
Sarcomere Organization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Heart Contraction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Spleen Development
Positive Regulation Of Cardioblast Differentiation
Ventricular Cardiac Myofibril Assembly
Cardiac Muscle Cell Differentiation
Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Regulation Of Cardiac Muscle Contraction
Pharyngeal System Development
Cardiac Muscle Cell Proliferation
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Contraction
Canonical Wnt Signaling Pathway
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Heart Trabecula Formation
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Atrioventricular Node Cell Development
Atrioventricular Node Cell Fate Commitment
Embryonic Heart Tube Left/right Pattern Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Voltage-gated Calcium Channel Activity
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Cardiac Muscle Hypertrophy In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Heart rate (
23583979
)
Infantile hypertrophic pyloric stenosis (
22306654
)
PR interval (
20062060
)
Protein-Protein Interactions
13 interactors:
CAMTA2
CSNK2A1
FOXH1
GATA4
HDAC1
HIPK1
HIPK2
JARID2
KDM6A
SRF
TBX2
TBX5
TLE1
4 interactors:
CALM2
CALM3
HDAC5
NKX2-5
Entrez ID
1482
23125
HPRD ID
02787
13002
Ensembl ID
ENSG00000183072
ENSG00000108509
Uniprot IDs
P52952
O94983
PDB IDs
3RKQ
Enriched GO Terms of Interacting Partners
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Organ Morphogenesis
Embryonic Morphogenesis
Transcription, DNA-templated
RNA Biosynthetic Process
Embryonic Organ Morphogenesis
Tissue Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
RNA Metabolic Process
Embryo Development
Anatomical Structure Morphogenesis
Heart Morphogenesis
Gene Expression
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Pattern Specification Process
Anterior/posterior Pattern Specification
Embryonic Organ Development
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Chamber Development
Organ Development
System Development
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Tissue Development
Cardiac Muscle Tissue Development
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Anatomical Structure Development
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Growth
Positive Regulation Of Cell Proliferation
Cellular Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Heart Development
Developmental Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Aorta Morphogenesis
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cardiac Muscle Cell Proliferation
Aorta Development
Striated Muscle Tissue Development
Regulation Of Voltage-gated Calcium Channel Activity
Positive Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Cation Channel Activity
Positive Regulation Of Ion Transmembrane Transporter Activity
Positive Regulation Of Transporter Activity
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Regulation Of Cardiac Muscle Contraction
Regulation Of Cation Channel Activity
Positive Regulation Of Ion Transmembrane Transport
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of Striated Muscle Contraction
Positive Regulation Of Calcium Ion Transport
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of High Voltage-gated Calcium Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Muscle Contraction
Regulation Of Heart Contraction
Negative Regulation Of Myotube Differentiation
Detection Of Calcium Ion
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Calcium Ion Transport
Positive Regulation Of Ion Transport
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Autophosphorylation
Muscle Contraction
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Glycogen Catabolic Process
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Striated Muscle Cell Differentiation
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Cation Channel Activity
Polysaccharide Catabolic Process
Muscle System Process
Positive Regulation Of Monooxygenase Activity
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Rhodopsin Mediated Signaling Pathway
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Activation Of Adenylate Cyclase Activity
Nitric Oxide Metabolic Process
Regulation Of Protein Autophosphorylation
Reactive Nitrogen Species Metabolic Process
Rhodopsin Mediated Signaling Pathway
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