NKX2-5 and SRF

Number of citations of the paper that reports this interaction (PMID 8887666)
62

Data Source:
HPRD (in vitro, in vivo)

		NKX2-5	SRF
Gene Name		NK2 homeobox 5	serum response factor (c-fos serum response element-binding transcription factor)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Transcription From RNA Polymerase II Promoter Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation BMP Signaling Pathway Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Voltage-gated Calcium Channel Activity	Patterning Of Blood Vessels Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long Term Synaptic Depression Heart Trabecula Formation Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Beta-amyloid Clearance
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060)
Protein-Protein Interactions		13 interactors: CAMTA2 CSNK2A1 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1	72 interactors: ALDH3A1 ASCC1 ASCC2 ASCC3 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CNTN2 CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MKL1 MKL2 MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARG REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 UBE2I ZIC3
Entrez ID		1482	6722
HPRD ID		02787	02788
Ensembl ID		ENSG00000183072	ENSG00000112658
Uniprot IDs		P52952	F5H6V4 P11831
PDB IDs		3RKQ	1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Embryonic Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryonic Organ Morphogenesis Tissue Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Metabolic Process Embryo Development Anatomical Structure Morphogenesis Heart Morphogenesis Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Pattern Specification Process Anterior/posterior Pattern Specification Embryonic Organ Development Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cardiac Chamber Development Organ Development System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Muscle Tissue Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Growth Positive Regulation Of Cell Proliferation Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heart Development Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Aorta Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardiac Muscle Cell Proliferation Aorta Development Striated Muscle Tissue Development	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organ Development Cell Differentiation Developmental Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Tissue Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Response To Lipid Anatomical Structure Development Regulation Of Cellular Process Anatomical Structure Morphogenesis System Development Response To Hormone Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Heart Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Response To Steroid Hormone Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process
Tagcloud ?			ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Difference) ?			ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Intersection) ?