NKX2-5 and SHOX

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NKX2-5	SHOX
Name		NK2 homeobox 5	SHOX homeobox
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis	None
Diseases		Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect	SHOX-related haploinsufficiency disorders, including: Isolated short stature; Langer syndrome; Leri-Weill syndrome
GWAS		Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heart rate ( 23583979 ) Infantile hypertrophic pyloric stenosis ( 22306654 ) PR interval ( 20062060 30046033 32439900 ) Resting heart rate ( 27798624 ) Stroke ( 26089329 ) TPE interval (resting) ( 32386560 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: FLT4	None recorded
Interacting Genes		19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10	5 interacting genes: CSNK2A1 GLIS2 HEMK1 IGBP1 NKX2-5
Entrez ID		1482	6473
HPRD ID		02787	02430
Ensembl ID		ENSG00000183072	ENSG00000185960
Uniprot IDs		A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952	O15266
PDB IDs		3RKQ 4S0H 6WC2 6WC5	Not available
GO Terms Enriched among Interactors		Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation	Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development N-methyltransferase Activity Positive Regulation Of Aggrephagy Negative Regulation Of Biosynthetic Process Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Membraneless Organelle Assembly Atrial Septum Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Wnt Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Muscle Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Adult Heart Development Heart Trabecula Formation Ventricular Trabecula Myocardium Morphogenesis