FOXH1 and UFSP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXH1	UFSP1
Description		forkhead box H1	UFM1 specific peptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeUFMylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Proteolysis Protein Maturation Protein Ufmylation
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 20639392 27798624 29769521)
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	43 interacting genes: C10orf55 CIDEB CIDEC COG6 CREB5 CSTF2 FAM222B FANCL FOXH1 FOXI1 GLYCTK GPSM3 HNF1B HOXC9 HSF4 INCA1 KRTAP15-1 LASP1 MSRB3 MYOZ3 PITX1 PITX2 POGZ POU6F2 PROP1 PRR22 RAPGEF3 RBM14 RBPMS2 RUSC1 SMARCC1 SNRPC SPG21 TBX3 TCF7L2 TLX3 UBQLN2 VAC14 VAX2 VGLL3 VPS37C WWOX ZIC1
Entrez ID		8928	402682
HPRD ID		04689	18630
Ensembl ID		ENSG00000160973	ENSG00000176125
Uniprot IDs		O75593	A0AAR1ZLH9 Q6NVU6
PDB IDs		5XOC 7YZB
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	DNA-binding Transcription Factor Activity Chromatin Embryonic Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Animal Organ Morphogenesis Pattern Specification Process Hepatoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Myoblast Fate Commitment DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process System Development Transcription Regulator Complex Central Nervous System Development Somatotropin Secreting Cell Differentiation Regulation Of Primary Metabolic Process Embryonic Hindlimb Morphogenesis Regionalization Gland Development Pituitary Gland Development Lipid Droplet Fusion Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Hindlimb Morphogenesis Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Transcription Cis-regulatory Region Binding Inner Ear Morphogenesis Outflow Tract Morphogenesis Lipid Transfer Activity Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Axis Specification
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