FOXH1 and NKX2-5

Number of citations of the paper that reports this interaction (PMID 15363409)
34

Data Source:
HPRD (in vitro)

		FOXH1	NKX2-5
Gene Name		forkhead box H1	NK2 homeobox 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Activin Responsive Factor Complex	Nucleus Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Enhancer Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Androgen Receptor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Transcription From RNA Polymerase II Promoter Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation BMP Signaling Pathway Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Signaling by Activin Signaling by NODAL	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060)
Protein-Protein Interactions		6 interactors: DRAP1 FOXG1 NKX2-5 SMAD2 SMAD3 SMAD4	13 interactors: CAMTA2 CSNK2A1 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		8928	1482
HPRD ID		04689	02787
Ensembl ID		ENSG00000160973	ENSG00000183072
Uniprot IDs		O75593	P52952
PDB IDs			3RKQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Differentiation SMAD Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Mesenchyme Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Endoderm Development Primary MiRNA Processing Embryonic Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Tube Morphogenesis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Pattern Specification Process Mesonephros Development Growth Positive Regulation Of Cell Development Heart Development Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Nodal Signaling Pathway RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Embryonic Morphogenesis Embryonic Foregut Morphogenesis Tissue Morphogenesis Response To Transforming Growth Factor Beta Foregut Morphogenesis Gastrulation Regulation Of Cellular Response To Growth Factor Stimulus Paraxial Mesoderm Development Gene Expression Tube Development Production Of MiRNAs Involved In Gene Silencing By MiRNA	Organ Morphogenesis Embryonic Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryonic Organ Morphogenesis Tissue Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Metabolic Process Embryo Development Anatomical Structure Morphogenesis Heart Morphogenesis Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Pattern Specification Process Anterior/posterior Pattern Specification Embryonic Organ Development Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cardiac Chamber Development Organ Development System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Muscle Tissue Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Growth Positive Regulation Of Cell Proliferation Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heart Development Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Aorta Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardiac Muscle Cell Proliferation Aorta Development Striated Muscle Tissue Development
Tagcloud ?		alphav antiangiogenic beta3 bioactivities dextran dishes epas1 epc epcs erg exponentially floating fosl1 gata1 hey1 hhex hif1a icam1 id1 medicines mmp9 nfkb1 r1 smad1 tie2 transductions vasculogenesis vcam1 ve
Tagcloud (Difference) ?		alphav antiangiogenic beta3 bioactivities dextran dishes epas1 epc epcs erg exponentially floating fosl1 gata1 hey1 hhex hif1a icam1 id1 medicines mmp9 nfkb1 r1 smad1 tie2 transductions vasculogenesis vcam1 ve
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