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NKX2-5 and HIPK1
Number of citations of the paper that reports this interaction (PMID
9748262
)
47
Data Source:
HPRD
(two hybrid, in vitro)
NKX2-5
HIPK1
Gene Name
NK2 homeobox 5
homeodomain interacting protein kinase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Transcription Factor Complex
Cytoplasm
RNA Polymerase II Transcription Factor Complex
Nucleus
Cytoplasm
PML Body
Nuclear Speck
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Cofactor Activity
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Vasculogenesis
Heart Looping
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Bundle Of His Development
Purkinje Myocyte Differentiation
Cardiac Ventricle Formation
Right Ventricular Cardiac Muscle Tissue Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Apoptotic Process Involved In Heart Morphogenesis
Septum Secundum Development
Proepicardium Development
Pulmonary Myocardium Development
Transcription From RNA Polymerase II Promoter
Adult Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Sodium Ion Transport
Negative Regulation Of Myotube Differentiation
Hemopoiesis
Cell Differentiation
BMP Signaling Pathway
Thyroid Gland Development
Embryonic Heart Tube Development
Negative Regulation Of Apoptotic Process
Sarcomere Organization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Heart Contraction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Spleen Development
Positive Regulation Of Cardioblast Differentiation
Ventricular Cardiac Myofibril Assembly
Cardiac Muscle Cell Differentiation
Cardiac Muscle Tissue Morphogenesis
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Regulation Of Cardiac Muscle Contraction
Pharyngeal System Development
Cardiac Muscle Cell Proliferation
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Contraction
Canonical Wnt Signaling Pathway
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Heart Trabecula Formation
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Atrioventricular Node Cell Development
Atrioventricular Node Cell Fate Commitment
Embryonic Heart Tube Left/right Pattern Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Voltage-gated Calcium Channel Activity
Eye Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Smoothened Signaling Pathway
Positive Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Retina Layer Formation
Neuron Differentiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Angiogenesis
Embryonic Camera-type Eye Morphogenesis
Embryonic Retina Morphogenesis In Camera-type Eye
Definitive Hemopoiesis
Lens Induction In Camera-type Eye
Iris Morphogenesis
Endothelial Cell Apoptotic Process
Extrinsic Apoptotic Signaling Pathway
Pathways
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Generic Transcription Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS
Heart rate (
23583979
)
Infantile hypertrophic pyloric stenosis (
22306654
)
PR interval (
20062060
)
Breast cancer (
23535729
)
Protein-Protein Interactions
13 interactors:
CAMTA2
CSNK2A1
FOXH1
GATA4
HDAC1
HIPK1
HIPK2
JARID2
KDM6A
SRF
TBX2
TBX5
TLE1
13 interactors:
ATP13A2
DAXX
FHL3
GLUL
HOXD4
NKX2-5
PARK7
PRPF40A
RUNX1
SKIL
SNIP1
TP53
UBE2I
Entrez ID
1482
204851
HPRD ID
02787
06418
Ensembl ID
ENSG00000183072
ENSG00000163349
Uniprot IDs
P52952
B4DZ33
Q86Z02
PDB IDs
3RKQ
Enriched GO Terms of Interacting Partners
?
Organ Morphogenesis
Embryonic Morphogenesis
Transcription, DNA-templated
RNA Biosynthetic Process
Embryonic Organ Morphogenesis
Tissue Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
RNA Metabolic Process
Embryo Development
Anatomical Structure Morphogenesis
Heart Morphogenesis
Gene Expression
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Pattern Specification Process
Anterior/posterior Pattern Specification
Embryonic Organ Development
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Chamber Development
Organ Development
System Development
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Tissue Development
Cardiac Muscle Tissue Development
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Anatomical Structure Development
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Growth
Positive Regulation Of Cell Proliferation
Cellular Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Heart Development
Developmental Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Aorta Morphogenesis
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cardiac Muscle Cell Proliferation
Aorta Development
Striated Muscle Tissue Development
Negative Regulation Of Gene Expression
Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Neurotransmitter Uptake
Positive Regulation Of Transport
Regulation Of Signaling
Regulation Of Transcription, DNA-templated
Regulation Of Intrinsic Apoptotic Signaling Pathway
RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Response To Toxic Substance
Cellular Response To Transforming Growth Factor Beta Stimulus
Gene Expression
Response To Transforming Growth Factor Beta
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Signal Transduction
Regulation Of Muscle Cell Apoptotic Process
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Muscle Organ Development
Positive Regulation Of Transporter Activity
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Neuron Death
Cell Proliferation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Response To Antibiotic
Negative Regulation Of Cell Differentiation
Nitrogen Compound Metabolic Process
Organelle Organization
Positive Regulation Of L-dopa Decarboxylase Activity
Positive Regulation Of L-dopa Biosynthetic Process
Glyoxal Catabolic Process
Positive Regulation Of Dopamine Biosynthetic Process
Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity
Atrioventricular Node Cell Fate Commitment
Positive Regulation Of Tyrosine 3-monooxygenase Activity
Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Tagcloud
?
1gamma
chromo
ddr
dead
doi
flag
gammah2a
h3k9me3
hct116
hipk2
homeodomain
hp1
hp1alpha
hp1beta
hp1box
hp1gamma
lys9
onc
phosphorylating
ptvsv
ser139
shadow
silenced
sublethal
tagged
trimethylated
ultraviolet
uncover
uv
Tagcloud (Difference)
?
1gamma
chromo
ddr
dead
doi
flag
gammah2a
h3k9me3
hct116
hipk2
homeodomain
hp1
hp1alpha
hp1beta
hp1box
hp1gamma
lys9
onc
phosphorylating
ptvsv
ser139
shadow
silenced
sublethal
tagged
trimethylated
ultraviolet
uncover
uv
Tagcloud (Intersection)
?