FOXH1 and AOC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FOXH1	AOC1
Name		forkhead box H1	amine oxidase copper containing 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Heparin Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Quinone Binding Putrescine Oxidase Activity Diamine Oxidase Activity Histamine Oxidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Amine Metabolic Process Putrescine Metabolic Process
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm	Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		None	Amiloride Calcium Diminazene Pimagedine
GWAS		Blood metabolite levels ( 26401656 ) Educational attainment ( 25201988 ) General cognitive ability ( 29844566 )	Anthropometric traits (multi-trait analysis) ( 30166351 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Carpal tunnel syndrome ( 30833571 ) Eyebrow thickness ( 26926045 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multisite chronic pain ( 33830993 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 30297969 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Novel Interactors		4 novel interactors: LRRC14 RECQL4 RPL8 SUPT20H	None recorded
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	14 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KLHL20 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10
Entrez ID		8928	26
HPRD ID		04689	00088
Ensembl ID		ENSG00000160973	ENSG00000002726
Uniprot IDs		O75593	P19801
PDB IDs		5XOC 7YZB	3HI7 3HIG 3HII 3K5T 3MPH
GO Terms Enriched among Interactors		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Cytoplasmic Stress Granule D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Type II Interferon Binding Protein-N-terminal Glutamine Amidohydrolase Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Protein K33-linked Ubiquitination Protein-N-terminal Asparagine Amidohydrolase Activity